Development of vaccines to treat opioid use disorders and reduce incidence of overdose

M Pravetoni, SD Comer - Neuropharmacology, 2019 - Elsevier
Vaccines offer a promising therapeutic strategy to treat substance use disorders (SUD).
Vaccines have shown extensive preclinical proof of selectivity, safety, and efficacy against …

Immunotherapies for the treatment of drug addiction

MK Hossain, M Davidson, E Kypreos, J Feehan… - Vaccines, 2022 - mdpi.com
Substance use disorders (SUD) are a serious public health concern globally. Existing
treatment platforms suffer from a lack of effectiveness. The development of immunotherapies …

Safety and efficacy of an oxycodone vaccine: Addressing some of the unique considerations posed by opioid abuse

MD Raleigh, SJ Peterson, M Laudenbach… - PLoS …, 2017 - journals.plos.org
Among vaccines aimed at treating substance use disorders, those targeting opioids present
several unique medication development challenges. 1) Opioid overdose is a common …

Preclinical efficacy and characterization of candidate vaccines for treatment of opioid use disorders using clinically viable carrier proteins

F Baruffaldi, AH Kelcher, M Laudenbach… - Molecular …, 2018 - ACS Publications
Vaccines may offer a new treatment strategy for opioid use disorders and opioid-related
overdoses. To speed translation, this study evaluates opioid conjugate vaccines containing …

Clinical trial design challenges and opportunities for emerging treatments for opioid use disorder: A review

BD Kiluk, BA Kleykamp, SD Comer, RR Griffiths… - JAMA …, 2023 - jamanetwork.com
Importance Novel treatments for opioid use disorder (OUD) are needed to address both the
ongoing opioid epidemic and long-standing barriers to existing OUD treatments that target …

Vaccines as immunotherapies for substance use disorders

TR Kosten - American Journal of Psychiatry, 2024 - Am Psychiatric Assoc
Substance use disorders (SUD) present a worldwide challenge with few effective therapies
except for the relative efficacy of opioid pharmacotherapies, despite limited treatment …

Immunotherapeutic strategies for treating opioid use disorder and overdose

R Luba, S Martinez, J Jones, M Pravetoni… - Expert opinion on …, 2023 - Taylor & Francis
Introduction Development and implementation of effective treatments for opioid use disorder
(OUD) and prevention of overdose are urgent public health needs. Though existing …

Vaccines against drugs of abuse: where are we now?

B Kinsey - Therapeutic advances in vaccines, 2014 - journals.sagepub.com
Drug addiction is a serious problem worldwide. One therapy being investigated is vaccines
against drugs of abuse. The antibodies elicited against the drug can take up the drug and …

Formulation and characterization of conjugate vaccines to reduce opioid use disorders suitable for pharmaceutical manufacturing and clinical evaluation

F Baruffaldi, MD Raleigh, SJ King… - Molecular …, 2019 - ACS Publications
This study focused on formulating conjugate vaccines targeting oxycodone and heroin for
technology transfer, good manufacturing practice (GMP), and clinical evaluation. Lead …

Ethical implications in vaccine pharmacotherapy for treatment and prevention of drug of abuse dependence

A Carfora, P Cassandro, A Feola, F La Sala… - Journal of bioethical …, 2018 - Springer
Different immunotherapeutic approaches are in the pipeline for the treatment of drug
dependence.“Drug vaccines” aim to induce the immune system to produce antibodies that …