Impaired protein homeostasis and accumulation of damaged or abnormally modified protein
are common disease mechanisms in many neurodegenerative disorders, including …

Understanding the function of genes mutated in hereditary forms of Parkinson's disease
yields insight into disease etiology and reveals new pathways in cell biology. Although …

Parkinson's disease (PD) is a chronic and progressive neurodegeneration of dopamine
neurons in the substantia nigra. The reason for the death of these neurons is unclear; …

Mitophagy is an evolutionarily conserved cellular process which selectively eliminates
dysfunctional mitochondria by targeting them to the autophagosome for degradation …

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from
aerobic metabolism, as a result of accidental electron leakage as well as regulated …

Reactive oxygen and nitrogen species change cellular responses through diverse
mechanisms that are now being defined. At low levels, they are signalling molecules, and at …

Neurodegenerative diseases, a subset of age-driven diseases, have been known to exhibit
increased oxidative stress. The resultant increase in reactive oxygen species (ROS) has …

S-Nitrosylation is a redox-mediated posttranslational modification that regulates protein
function via covalent reaction of nitric oxide (NO)-related species with a cysteine thiol group …

Mutations in parkin lead to early-onset autosomal recessive Parkinson's disease (PD) and
inactivation of parkin is thought to contribute to sporadic PD. Adult knockout of parkin in the …

Autophagy is a ubiquitous homeostatic mechanism for the degradation or turnover of cellular
components. Degradation of mitochondria via autophagy (mitophagy) is involved in a …