This article focuses on the different types of transporter proteins that have been implicated in
the influx and efflux of nucleoside-derived drugs currently used in the treatment of cancer …

Equilibrativenucleoside transporters (ENTs) participate in the pharmacokinetics and
disposition of nucleoside analog drugs. Understanding drug interactions with the ENTs may …

Ribavirin is frontline treatment for hepatitis C virus infection. To determine the role of
nucleoside transporters in the intestinal absorption of orally administered ribavirin, we …

The aim of the present study was to investigate the genetic factors responsible for the
interindividual variability in the bioavailability of mizoribine. Thirty healthy Japanese men …

Mizoribine, an immunosuppressive anti‐metabolite, is largely excreted into urine in its
unchanged form, and its pharmacokinetics has been considered to be dependent on the …

Background The aim of the present study was to estimate the population pharmacokinetic
parameters of mizoribine in adult recipients of renal transplantation using a nonlinear mixed …

Bioavailability of mizoribine in subjects with the concentrative nucleoside transporter 1
(CNT1, SLC28A1) 565-A/A allele is significantly lower than that in subjects with the …

MATERIALS AND METHODS Materials [14C] Tetraethylammonium (TEA) bromide (2.04
GBq/mmol),[3H] quinidine (740 GBq/mmol),[14C] procainamide hydrochloride (2.04 …

Mizoribine monophosphate (MZP) is a specific inhibitor of the cellular inosine-5′-
monophosphate dehydrogenase (IMPDH), the enzyme catalyzing the rate-limiting step of de …

Background The present study aimed to obtain information enabling optimisation of the
clinical effect of mizoribine (MZR) in pediatric patients with kidney disease. Methods A total …