Urokinase-type plasminogen activator (uPA) is a serine protease involved in tissue
remodeling and cell migration. At the gene level, the interplay between a complex enhancer …

Transforming growth factor‐beta (TGF‐β) is a pleiotropic factor, with several different roles in
health and disease. TGF‐β has been postulated as a dual factor in tumor progression, since …

The transcription factor Sp1 regulates the expression of multiple genes. However, its
expression and role in human tumor development and progression remain unclear. Using …

The biological and clinical behaviors of cancer are affected by multiple molecular pathways
that are under the control of transcription factors. Improved understanding of how …

Myosin VI is the only myosin that moves toward the minus end of actin filaments, suggesting
a unique biological function. Here, we show that myosin VI is present in the nucleus of …

Sp1 is a transcription factor for many genes, including genes involved in tumorigenesis. We
found that human fibroblast cells malignantly transformed in culture by a carcinogen or by …

Although protein kinase D3 (PKD3) has been shown to contribute to prostate cancer cell
growth and survival, the role of PKD in prostate cancer cell motility remains unclear. Here …

CD147 is a novel cancer‐associated biomarker that plays an important role in the invasion
and metastasis of human lung cancer. In spite of its many known functions, little is known …

GATA6 is a zinc finger transcription factor expressed in the colorectal epithelium. We have
examined the expression of GATA6 in colon cancers and investigated the mechanisms by …

RING finger proteins have been implicated in many fundamental cellular processes,
including the control of gene expression. A key regulator of light-dependent development in …