Advanced and recurrent gynecological cancers are associated with poor prognosis and lack
of effective treatment. The developments of the molecular mechanisms on cancer …

Human ALDH comprise 19 subfamilies in which ALDH1A1, ALDH1A3, ALDH3A1,
ALDH5A1, ALDH7A1, and ALDH18A1 are implicated in CSC. Studies have shown that …

Compared with traditional therapies, targeted therapy has merits in selectivity, efficacy, and
tolerability. Small molecule inhibitors are one of the primary targeted therapies for cancer …

Cancer cell dormancy is a common feature of human tumors and represents a major clinical
barrier to the long-term efficacy of anticancer therapies. Dormant cancer cells, either in …

Solid tumors can be divided into benign solid tumors and solid malignant tumors in the
academic community, among which malignant solid tumors are called cancers. Cancer is …

Targeting bromodomain and extra-terminal domain (BET) proteins has shown a promising
therapeutic effect on melanoma. The development of strategies to better kill melanoma cells …

Distant recurrences occurring years after removal of the primary tumor arise from
disseminated tumor cells (DTCs) that lie dormant (quiescent/asymptomatic) until they …

The majority of women diagnosed with epithelial ovarian cancer eventually develop
recurrence, which rapidly evolves into chemoresistant disease. Persistence of ovarian …

Mitogen‐activated protein kinase (MAPK) signaling pathway is activated in a wide spectrum
of human tumors, exhibiting cardinal oncogenic roles and sustained inhibition of this …

Induction of ferroptosis is an emerging strategy to suppress melanoma progression.
Strategies to enhance the sensitivity to ferroptosis induction would be a major advance in …