Inflammation: Biochemistry, cellular targets, anti-inflammatory agents and challenges with special emphasis on cyclooxygenase-2
B Kaur, P Singh - Bioorganic Chemistry, 2022 - Elsevier
Keeping in view the involvement of inflammation in the pathogenesis of several diseases
including cancer, diabetes, neurodegenerative disorders and rheumatoid arthritis, herein …
including cancer, diabetes, neurodegenerative disorders and rheumatoid arthritis, herein …
Inhibitory activities of indolizine derivatives: a patent review
Introduction Indolizines are structural isomers with indoles. Although several indole-based
commercial drugs are available in the market, none of the indolizine-based drugs are …
commercial drugs are available in the market, none of the indolizine-based drugs are …
[HTML][HTML] Alkaloids: therapeutic potential against human coronaviruses
BC Fielding, C da Silva Maia Bezerra Filho, NSM Ismail… - Molecules, 2020 - mdpi.com
Alkaloids are a class of natural products known to have wide pharmacological activity and
have great potential for the development of new drugs to treat a wide array of pathologies …
have great potential for the development of new drugs to treat a wide array of pathologies …
Design, synthesis, characterization, and anti-tubercular activity of novel ethyl-3-benzoyl-6, 8-difluoroindolizine-1-carboxylate analogues: Molecular target identification …
P Mundhe, S Kidwai, SM Saini, HR Singh… - Journal of Molecular …, 2023 - Elsevier
A series of novel Ethyl-3-benzoyl-6, 8-difluoroindolizine-1-carboxylate analogues (4a-r)
were synthesized by reacting 3, 5-difluoropyridine, with phenacyl bromide to get quaternary …
were synthesized by reacting 3, 5-difluoropyridine, with phenacyl bromide to get quaternary …
Anti-tubercular activity and molecular docking studies of indolizine derivatives targeting mycobacterial InhA enzyme
KN Venugopala, S Chandrashekharappa… - Journal of Enzyme …, 2021 - Taylor & Francis
Abstract A series of 1, 2, 3-trisubstituted indolizines (2a–2f, 3a–3d, and 4a–4c) were
screened for in vitro whole-cell anti-tubercular activity against the susceptible H37Rv and …
screened for in vitro whole-cell anti-tubercular activity against the susceptible H37Rv and …
Investigation of antifungal properties of synthetic dimethyl-4-bromo-1-(substituted benzoyl) pyrrolo [1, 2-a] quinoline-2, 3-dicarboxylates analogues: Molecular docking …
V Uppar, S Chandrashekharappa, C Shivamallu, SP… - Molecules, 2021 - mdpi.com
Candida albicans, an opportunistic fungal pathogen, frequently colonizes immune-
compromised patients and causes mild to severe systemic reactions. Only few antifungal …
compromised patients and causes mild to severe systemic reactions. Only few antifungal …
Tandem-Michael-cyclization cascade to make pyridines: Use of electron-deficient acetylenes for the synthesis of indolizines in aqueous media
K Lakshmikanth, SM Saini, ST Dorai… - Tetrahedron, 2023 - Elsevier
A mild, greener approach via tandem-Michael-cyclization cascade reaction towards the
construction of a group of di-and tri-differently substituted indolizine with a broad scope of …
construction of a group of di-and tri-differently substituted indolizine with a broad scope of …
Anti-tubercular activity of substituted 7-methyl and 7-formylindolizines and in silico study for prospective molecular target identification
Novel series of diversely substituted indolizines were designed, synthesized, and evaluated
for their in vitro anti-mycobacterial activity against H37Rv and multi-drug-resistant (MDR) …
for their in vitro anti-mycobacterial activity against H37Rv and multi-drug-resistant (MDR) …
Microwave-assisted improved regioselective synthesis of 3-benzoyl indolizine derivatives
An efficient and facile method is developed to synthesize 3-benzoyl indolizines by two-
component reaction under microwave irradiation. A wide range of substrates could be …
component reaction under microwave irradiation. A wide range of substrates could be …
Synthesis and characterization of pyrrolo[1,2-a]quinoline derivatives for their larvicidal activity against Anopheles arabiensis
V Uppar, S Chandrashekharappa, KN Venugopala… - Structural Chemistry, 2020 - Springer
Abstract Certain tetrahydropyrido [1, 2-a] quinolines and pyrroloquinoline homologs have
shown various biological activities such as antimicrobials, crop-protectings, diuretics …
shown various biological activities such as antimicrobials, crop-protectings, diuretics …