MicroRNAs (miRNAs) are members of a non-coding RNA family. They act as negative
regulators of protein translation by affecting messenger RNA (mRNA) stability; they …

MicroRNAs (miRNAs) are increasingly recognized to play important roles in cardiovascular
diseases, including heart failure. These small, non‐coding RNAs have been identified in …

Aims Sustained cardiac hypertrophy accompanied by maladaptive cardiac remodelling
represents an early event in the clinical course leading to heart failure. Maladaptive …

Unintended cardiac fibroblast proliferation in many pathophysiological heart conditions,
known as cardiac fibrosis, results in pooling of extracellular matrix (ECM) proteins in the …

In cardiomyocytes, invaginations of the sarcolemmal membrane called t-tubules are critically
important for triggering contraction by excitation-contraction (EC) coupling. These structures …

Junctophilins (JPHs) comprise a family of structural proteins that connect the plasma
membrane to intracellular organelles such as the endo/sarcoplasmic reticulum (ER/SR) …

Heart failure is a leading cause of death in industrialized nations especially in an aging
population. The recent improvements in cardiac revascularization therapy reduced death …

Cardiac excitation–contraction coupling occurs primarily at the sites of transverse (T)-
tubule/sarcoplasmic reticulum junctions. The orderly T-tubule network guarantees the …

INTRODUCTION Cardiac excitation-contraction (EC) coupling refers to a cascade of Ca2+-
mediated events whereby membrane depolarization leads to cell contraction. At the …

In mammalian cardiac myocytes, the plasma membrane includes the surface sarcolemma
but also a network of membrane invaginations called transverse (t-) tubules. These …