The folate receptor (FR) is a recognised biomarker for tumour cells due to its overexpression
on a large number of tumours. Consequently, the FR has been exploited by many diagnostic …

Promising targeted treatments and immunotherapy strategies in oncology and
advancements in our understanding of molecular pathways that underpin cancer …

Targeted therapy has become an effective strategy of precision medicine for improving
cancer treatment. Selectivity improvement is always popular in modern oncology because of …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

The folate receptor (FR) is a potentially useful biological target for the management of many
human cancers. This membrane protein binds extracellular folates with very high affinity …

The targeted delivery of potent cytotoxic agents has emerged as a promising strategy for the
treatment of cancer and other serious conditions. Traditionally, antibodies against markers of …

A majority of ovarian and non–small cell lung adenocarcinoma cancers overexpress folate
receptor α (FRα). Here, we report the development of an anti-FRα antibody–drug conjugate …

Traditional chemotherapy mostly relies on the use of cytotoxic agents, which are typically
unable to preferentially localize at the tumor microenvironment resulting in off-target toxicity …

Targeted delivery combined with controlled release of drugs has a crucial role in future of
personalized medicine. The majority of cancer drugs are intended to interfere with one or …

The main benefit of natural peptides, peptide analogs and newly designed peptides as
therapeutics, lies in their high selectivity and affinity, which are frequently in the nanomolar …