The beating of the heart is a synchronized contraction of muscle cells (myocytes) that is
triggered by a periodic sequence of electrical waves (action potentials) originating in the …

Human embryonic stem cells have emerged as the prototypical source from which
cardiomyocytes can be derived for use in drug discovery and cell therapy. However, such …

In pathological conditions such as ischemic cardiomyopathy and heart failure, differentiation
of fibroblasts into myofibroblasts may result in myocyte-fibroblast electrical coupling via gap …

Dimensionless quantities, such as p, e, and f are used in mathematics, engineering, physics,
and chemistry. In recent years the dimensionless groups, as demonstrated in detail here …

Signal transmission among cells enables long-range coordination in biological systems.
However, the scarcity of quantitative measurements hinders the development of theories that …

Patterns are everywhere in nature-in the ranks of clouds in the sky, the stripes of an
angelfish, the arrangement of petals in flowers. Where does this order and regularity come …

Arrhythmias in cardiac tissue are related to irregular electrical wave propagation in the heart.
Cardiac tissue is formed by a discrete cell network, which is often heterogeneous. A …

Coupled nonlinear system of reaction–diffusion equations describing multi-component
(species) interactions with heterogeneous coefficients is considered. Finite volume method …

The number of myenteric interstitial cells of Cajal (ICC‐MY), responsible for the generation
and propagation of the slow wave in the small intestine, has been shown to decrease in …

Many tissues are gap-junction-coupled syncytia that support cell-to-cell communication via
propagating calcium waves. This also holds true for pancreatic islets of Langerhans, where …