Nanoparticle drug delivery systems and their applications as targeted therapies for triple negative breast cancer

X Kong, Y Qi, X Wang, R Jiang, J Wang, Y Fang… - Progress in Materials …, 2023 - Elsevier
The therapeutic effect of highly malignant triple negative breast cancer (TNBC) is negatively
affected by the formation of tumor cell resistant clone and the severe toxicity of …

Nanoparticle surface functionalization: how to improve biocompatibility and cellular internalization

G Sanità, B Carrese, A Lamberti - Frontiers in molecular biosciences, 2020 - frontiersin.org
The use of nanoparticles (NP) in diagnosis and treatment of many human diseases,
including cancer, is of increasing interest. However, cytotoxic effects of NPs on cells and the …

Ligand‐installed nanocarriers toward precision therapy

P Mi, H Cabral, K Kataoka - Advanced Materials, 2020 - Wiley Online Library
Abstract Development of drug‐delivery systems that selectively target neoplastic cells has
been a major goal of nanomedicine. One major strategy for achieving this milestone is to …

Functionalizing nanoparticles with cancer-targeting antibodies: A comparison of strategies

AC Marques, PJ Costa, S Velho, MH Amaral - Journal of controlled release, 2020 - Elsevier
Standard cancer therapies sometimes fail to deliver chemotherapeutic drugs to tumor cells
in a safe and effective manner. Nanotechnology takes the lead in providing new therapeutic …

Polymeric micelles for anticancer drug delivery

N Majumder, NG Das, SK Das - Therapeutic delivery, 2020 - Taylor & Francis
Polymeric micelles have gained interest as novel drug delivery systems for the treatment
and diagnosis of cancer, as they offer several advantages over conventional drug therapies …

Antibody‐incorporated nanomedicines for cancer therapy

SY Wu, FG Wu, X Chen - Advanced Materials, 2022 - Wiley Online Library
Antibody‐based cancer therapy, one of the most significant therapeutic strategies, has
achieved considerable success and progress over the past decades. Nevertheless …

Nanocarriers address intracellular barriers for efficient drug delivery, overcoming drug resistance, subcellular targeting and controlled release

J Liu, H Cabral, P Mi - Advanced Drug Delivery Reviews, 2024 - Elsevier
The cellular barriers are major bottlenecks for bioactive compounds entering into cells to
accomplish their biological functions, which limits their biomedical applications …

Bridging smart nanosystems with clinically relevant models and advanced imaging for precision drug delivery

Q Zhou, Q Liu, Y Wang, J Chen, O Schmid… - Advanced …, 2024 - Wiley Online Library
Intracellular delivery of nano‐drug‐carriers (NDC) to specific cells, diseased regions, or
solid tumors has entered the era of precision medicine that requires systematic knowledge …

Modular synthesis of semiconducting graft copolymers to achieve “clickable” fluorescent nanoparticles with long circulation and specific cancer targeting

A Creamer, AL Fiego, A Agliano… - Advanced …, 2024 - Wiley Online Library
Semiconducting polymer nanoparticles (SPNs) are explored for applications in cancer
theranostics because of their high absorption coefficients, photostability, and …

A Hoechst Reporter Enables Visualization of Drug Engagement In Vitro and In Vivo: Toward Safe and Effective Nanodrug Delivery

T Miyazaki, S Chen, S Florinas, K Igarashi… - Acs Nano, 2022 - ACS Publications
Assessment of drug activation and subsequent interaction with targets in living tissues could
guide nanomedicine design, but technologies enabling insight into how a drug reaches and …