Multipotent stromal cells (MSCs) are vital for development, maintenance, function, and
regeneration of most tissues. They can differentiate along multiple connective lineages, but …

Mesenchymal stem cells (MSC) are multipotent cells, functioning as precursors to a variety
of cell types including adipocytes, osteoblasts, and chondrocytes. Between osteogenic and …

Bone formation in mammals requires continuous production of osteoblasts throughout life. A
common molecular marker for all osteogenic mesenchymal progenitors has not been …

To investigate roles for bone marrow adipocyte (BMAd) lipolysis in bone homeostasis, we
created a BMAd-specific Cre mouse model in which we knocked out adipose triglyceride …

The adult human skeleton is a multifunctional organ undergoing continuous remodeling.
Homeostasis of bone mass in a healthy adult requires an exquisite balance between bone …

Osteocytes,> 90% of the cells in bone, lie embedded within the mineralized matrix and
coordinate osteoclast and osteoblast activity on bone surfaces by mechanisms still unclear …

WNT signaling controls many biological processes including cell differentiation in
metazoans. However, how WNT reprograms cell identity is not well understood. We have …

Osteoporosis is a skeletal disorder characterized by bone loss, which results in architectural
deterioration of the skeleton, compromised bone strength and an increased risk of fragility …

Terminal differentiation of multipotent stem cells is achieved through a coordinated cascade
of activated transcription factors and epigenetic modifications that drive gene transcription …

Indian hedgehog (Ihh) is indispensable for development of the osteoblast lineage in the
endochondral skeleton. In order to determine whether Ihh is directly required for osteoblast …