Abstract Peripheral myelin protein-22 (PMP22) is primarily expressed in the compact myelin
of the peripheral nervous system. Levels of PMP22 have to be tightly regulated since …

By imposing saltatory conduction on the nervous impulse, the principal role of the myelin
sheath is to allow the faster propagation of action potentials along the axons which it …

Neurofibromas are one of the most characteristic features of neurofibromatosis type 1 (NF1),
an inherited autosomal-dominant neurogenetic disorder affecting 1 in 3500 individuals …

Neu-differentiation factor (glial growth factor) has been established as an important regulator
of early Schwann cell development, and the lineage relationship between immature …

Progesterone is synthesized in the nervous system by neurons and glial cells. Because of
their simple structure, plasticity and capacity of regeneration, peripheral nerves are …

Schwann cells express low levels of myelin proteins in the absence of neurons. When
Schwann cells and neurons are cultured together the production of myelin proteins is …

Protein zero (P0) and peripheral myelin protein 22 (PMP22) are most prominently expressed
by myelinating Schwann cells as components of compact myelin of the peripheral nervous …

Peripheral neuropathies of genetic etiology are a very diverse group of disorders
manifesting either as non-syndromic inherited neuropathies without significant …

The peripheral myelin gene PMP22 is the rat and human homologue of the murine growth
arrest‐specific gene gas3. Besides a putative role of PMP22 in myelination, a regulatory …

Abstract Charcot-Marie-Tooth 1A (CMT1A) is the most common inherited neuropathy without
a known therapy, which is caused by a 1.4 Mb duplication on human chromosome 17, which …