Status epilepticus is a life-threatening neurological emergency that affects both adults and
children. Approximately 36% of episodes of status epilepticus do not respond to the current …

Positive allosteric modulators of γ-aminobutyric acid-A (GABA A) receptors or GABAkines
have been widely used medicines for over 70 years for anxiety, epilepsy, sleep, and other …

Abstract γ-Aminobutyric acid (GABA) is the most prevalent inhibitory neurotransmitter in the
mammalian brain and has been found to play an important role in the pathogenesis or the …

Major depressive disorder (MDD) is a common mental disorder with a high rate of morbidity
and mortality. Dysfunctional signaling of gamma-aminobutyric acid (GABA) has been …

Objective Patients with refractory status epilepticus (RSE) have failed treatment with
benzodiazepines and≥ 1 second‐line intravenous (IV) antiseizure medication (ASM) …

GABA-A receptors play a pivotal role in many brain diseases. Epilepsy is caused by
acquired conditions and genetic defects in GABA receptor channels regulating neuronal …

Cardiac arrest is common and deadly, affecting up to 700 000 people in the United States
annually. Advanced cardiac life support measures are commonly used to improve outcomes …

Purpose To summarize the pathophysiology of convulsive status epilepticus (SE) with a
focus on practical implications for treatment. Method Narrative review of the medical …

Refractory and super-refractory status epilepticus (SE) are serious illnesses with a high risk
of morbidity and even fatality. In the setting of refractory generalized convulsive SE (GCSE) …

GABAkines, or positive allosteric modulators of γ-aminobutyric acid-A (GABA A) receptors,
are used for the treatment of anxiety, epilepsy, sleep, and other disorders. The search for …