Neuroinflammation is a central mechanism involved in neurodegeneration as observed in
Alzheimer's disease (AD), the most prevalent form of neurodegenerative disease …

Decades of neurobiological research have disclosed the diverse manners in which the
response properties of neurons are dynamically modulated to support adaptive cognitive …

Compelling experimental evidence suggests that microglial activation is involved in the
spread of tau tangles over the neocortex in Alzheimer's disease (AD). We tested the …

The recent availability of comprehensive, brain-wide gene expression atlases such as the
Allen Human Brain Atlas (AHBA) has opened new opportunities for understanding how …

Studies of large-scale brain organization have revealed interesting relationships between
spatial gradients in brain maps across multiple modalities. Evaluating the significance of …

Possession of the ε4 allele of apolipoprotein E (APOE) is the primary genetic risk factor for
the sporadic form of Alzheimer's disease (AD). While researchers have extensively …

Animal studies suggest that the apolipoprotein E ε4 (APOE ε4) allele is a culprit of early
microglial activation in Alzheimer's disease (AD). Here, we tested the association between …

Complex cognitive functions such as working memory and decision-making require
information maintenance over seconds to years, from transient sensory stimuli to long-term …

Importance Apolipoprotein E ε4 (APOEε4) is the single most important genetic risk factor for
Alzheimer disease. WhileAPOEε4is associated with increased amyloid-β burden, its …

The apolipoprotein E (APOE) ε4 allele is strongly linked with cerebral β-amyloidosis, but its
relationship with tauopathy is less established. We investigated the relationship between …