α-Crystallins in the vertebrate eye lens: Complex oligomers and molecular chaperones
MA Sprague-Piercy, MA Rocha… - Annual review of …, 2021 - annualreviews.org
α-Crystallins are small heat-shock proteins that act as holdase chaperones. In humans, αA-
crystallin is expressed only in the eye lens, while αB-crystallin is found in many tissues. α …
crystallin is expressed only in the eye lens, while αB-crystallin is found in many tissues. α …
Role of ATP-small heat shock protein interaction in human diseases
Adenosine triphosphate (ATP) is an important fuel of life for humans and Mycobacterium
species. Its potential role in modulating cellular functions and implications in systemic …
species. Its potential role in modulating cellular functions and implications in systemic …
The Sensory Shark: High-quality Morphological, Genomic and Transcriptomic Data for the Small-spotted Catshark Scyliorhinus Canicula Reveal the Molecular Bases …
Cartilaginous fishes (chondrichthyans: chimeras and elasmobranchs-sharks, skates, and
rays) hold a key phylogenetic position to explore the origin and diversifications of jawed …
rays) hold a key phylogenetic position to explore the origin and diversifications of jawed …
Unveiling the structural and functional consequences of the p. D109G pathogenic mutation in human αB-Crystallin responsible for restrictive cardiomyopathy and …
MH Jafari, MB Shahsavani, M Hoshino, J Hong… - International Journal of …, 2024 - Elsevier
Abstract αB-Crystallin (αB-Cry) is expressed in many tissues, and mutations in this protein
are linked to various diseases, including cataracts, Alzheimer's disease, Parkinson's …
are linked to various diseases, including cataracts, Alzheimer's disease, Parkinson's …
Temporal regulation of gene expression through integration of p53 dynamics and modifications
The master regulator of the DNA damage response, the transcription factor p53, orchestrates
multiple downstream responses and coordinates repair processes. In response to double …
multiple downstream responses and coordinates repair processes. In response to double …
Neonatal Severe Hyperparathyroidism: Novel Insights From Calcium, PTH, and the CASR Gene
SJ Marx, N Sinaii - The Journal of Clinical Endocrinology & …, 2020 - academic.oup.com
Context Neonatal severe hyperparathyroidism (NSHPT) is rare and potentially lethal. It is
usually from homozygous or heterozygous germline-inactivating CASR variant (s). NSHPT …
usually from homozygous or heterozygous germline-inactivating CASR variant (s). NSHPT …
Investigating the role of double mutations R12C/P20R, and R12C/R69C on structure, chaperone-like activity, and amyloidogenic properties of human αB-crystallin
SH Khaleghinejad, MB Shahsavani… - International Journal of …, 2023 - Elsevier
Abstract α-crystallin is a structurally essential small heat shock protein (sHSP) with a
chaperone-like activity which maintains transparency of the lenticular tissues during a period …
chaperone-like activity which maintains transparency of the lenticular tissues during a period …
Structural and functional characterization of D109H and R69C mutant versions of human αB-crystallin: the biochemical pathomechanism underlying cataract and …
M Ghahramani, R Yousefi, A Krivandin… - International journal of …, 2020 - Elsevier
In human αB-crystallin (αB-Cry), the highly conserved residues arginine 69 (R69) and
aspartate 109 (D109) are located within a critical motif of α-crystallin domain (ACD) …
aspartate 109 (D109) are located within a critical motif of α-crystallin domain (ACD) …
Arginine Reduces Glycation in γ2 Subunit of AMPK and Pathologies in Alzheimer's Disease Model Mice
R Zhu, Y Lei, F Shi, Q Tian, X Zhou - Cells, 2022 - mdpi.com
The metabolism disorders are a common convergence of Alzheimer's disease (AD) and type
2 diabetes mellitus (T2DM). The characteristics of AD are senile plaques and neurofibrillary …
2 diabetes mellitus (T2DM). The characteristics of AD are senile plaques and neurofibrillary …
The impact of different mutations at Arg54 on structure, chaperone-like activity and oligomerization state of human αA-crystallin: The pathomechanism underlying …
K Khoshaman, R Yousefi, AM Tamaddon… - … et Biophysica Acta (BBA …, 2017 - Elsevier
A major part of cataractogenic mutations in human αA-Crystallin (αA-Cry) occurs at Arg
residues. While Arg54 is highly conserved within different species, the cataractogenic …
residues. While Arg54 is highly conserved within different species, the cataractogenic …