Heterotrimeric G-proteins are intracellular partners of G-protein-coupled receptors (GPCRs).
GPCRs act on inactive Gα· GDP/Gβγ heterotrimers to promote GDP release and GTP …

G protein βγ subunits are central participants in G protein-coupled receptor signaling
pathways. They interact with receptors, G protein α subunits and downstream targets to …

The heterotrimeric G-protein alpha subunit has long been considered a bimodal, GTP-
hydrolyzing switch controlling the duration of signal transduction by seven-transmembrane …

Heterotrimeric G-proteins (Gαβγ) are the main transducers of signals from GPCRs,
mediating the action of countless natural stimuli and therapeutic agents. However, there are …

G protein βγ subunits have potential as a target for therapeutic treatment of a number of
diseases. We performed virtual docking of a small-molecule library to a site on Gβγ subunits …

An important function of the endothelium is to regulate the transport of liquid and solutes
across the semi-permeable vascular endothelial barrier. Two cellular pathways controlling …

▪ Abstract The GoLoco motif is a 19-amino-acid sequence with guanine nucleotide
dissociation inhibitor activity against G-alpha subunits of the adenylyl-cyclase-inhibitory …

G proteins play a central role in signal transduction and pharmacology. Signaling is initiated
by cell-surface receptors, which promote guanosine triphosphate (GTP) binding and …

▪ Abstract Accessory proteins involved in signal processing through heterotrimeric G proteins
are generally defined as proteins distinct from G protein–coupled receptor (GPCR), G …

Guanine nucleotide-binding proteins, G proteins, propagate incoming messages from
receptors to effector proteins. They switch from an inactive to active state by exchanging a …