Abstract Dapsone (4, 4′-diaminodiphenylsulfone) is an aniline derivative belonging to the
group of synthetic sulfones. In 1937 against the background of sulfonamide era the microbial …

In their 60-year history, dapsone and the sulfones have been used as both antibacterial and
anti-inflammatory agents. Dapsone has been used successfully to treat a range of …

In this new edition of a bestseller, all the contents have been brought upto-date by
addressing current standards and best practices in the assessment and prediction of …

An iridium catalyst–stabilized by an anionic P, N ligand–was used for the symmetrical and
unsymmetrical monoalkylation of para‐, meta‐, and ortho‐benzenediamines. Benzyl and …

In the past, sulfones were used preferentially as antimicrobial/chemotherapeutic agents to
treat infections caused by streptococcus, mycobacteriaceae, and other bacteria. 1 Currently …

Introduction: In their 70-year history, dapsone and other sulfones have been used as both
antibacterial and anti-inflammatory agents. Dapsone has been the main active principle in …

The differential incidence of adverse drug reactions (ADR) between trimethoprim-
sulfamethoxazole and dapsone might be explained, in part, by differences in the inherent …

Many adverse drug reactions are caused by the cytochrome P450 (CYP) dependent
activation of drugs into reactive metabolites. In order to reduce attrition due to metabolism …

We have modeled here chronic Daphnia toxicity taking pNOEC (negative logarithm of no
observed effect concentration in mM) and pEC 50 (negative logarithm of half-maximal …

The homodimeric flavoenzyme glutathione reductase catalyzes NADPH-dependent
glutathione disulfide reduction. This reaction is important for keeping the redox homeostasis …