Background The personality traits of positive and negative urgency refer to the tendencies to
act rashly when experiencing unusually positive or negative emotions, respectively …

Functional significance of delta oscillations is not fully understood. One way to approach this
question would be from an evolutionary perspective. Delta oscillations dominate the EEG of …

Behaviors and disorders related to self-regulation, such as substance use, antisocial
behavior and attention-deficit/hyperactivity disorder, are collectively referred to as …

Accumulation of lactate in the tissue microenvironment is a feature of both inflammatory
disease and cancer. Here, we assess the response of immune cells to lactate in the context …

Studying how genetic predispositions come together with environmental factors to contribute
to complex behavioral outcomes has great potential for advancing the understanding of the …

GABAA (γ-aminobutyric acid, type A) receptors are a family of ligand-gated ion channels that
are essential for the regulation of central nervous system function. Benzodiazepines—which …

Common variants at only two loci, FTO and MC4R, have been reproducibly associated with
body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of …

Benzodiazepines have been in use for over half a century. While they remain highly
prescribed, their unfavorable side-effect profile and abuse liability motivated a search for …

Genetic variation may partially underlie complex personality and physiological traits—such
as impulsivity, risk taking and stress responsivity—as well as a substantial proportion of …

The addictions are common chronic psychiatric diseases that today are prevented and
treated using relatively untargeted and only partially effective methods. The addictions are …