Technologies for imaging the pathophysiology of Alzheimer disease (AD) now permit
studies of the relationships between the two major proteins deposited in this disease …

The vast increase in Alzheimer disease (AD) worldwide has grave implications for
individuals, family support systems and the health-care systems that will attempt to cope with …

Abstract “The Scaffolding Theory of Aging and Cognition (STAC)”, proposed in 2009, is a
conceptual model of cognitive aging that integrated evidence from structural and functional …

With advances in healthcare and an ageing population, the number of older adults with
epilepsy is set to rise substantially across the world. In developed countries the highest …

A major mystery of many types of neurological and psychiatric disorders, such as
Alzheimer's disease (AD), remains the underlying, disease-specific neuronal damage …

The present article reviews theories of memory and aging over the past 50 years.
Particularly notable is a progression from early single-mechanism perspectives to complex …

Alzheimer's disease researchers have been intrigued by the selective regional vulnerability
of the brain to amyloid-β plaques and tau neurofibrillary tangles. Post-mortem studies …

Cross-sectional functional magnetic resonance imaging studies using a memory task in
patients with mild cognitive impairment have produced discordant results, with some studies …

Brain aging is characterized by considerable heterogeneity, including varying degrees of
dysfunction in specific brain systems, notably a medial temporal lobe memory system and a …

Background Alzheimer's disease (AD) pathology impairs cognitive function. Yet some
individuals with high amounts of AD pathology suffer marked memory impairment, while …