Methodology-centered review of molecular modeling, simulation, and prediction of SARS-CoV-2

K Gao, R Wang, J Chen, L Cheng, J Frishcosy… - Chemical …, 2022 - ACS Publications
Despite tremendous efforts in the past two years, our understanding of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune …

[HTML][HTML] RdRp (RNA-dependent RNA polymerase): A key target providing anti-virals for the management of various viral diseases

S Pathania, RK Rawal, PK Singh - Journal of Molecular Structure, 2022 - Elsevier
With the arrival of the Covid-19 pandemic, anti-viral agents have regained center stage in
the arena of medicine. Out of the various drug targets involved in managing RNA-viral …

Expression profile and localization of SARS-CoV-2 nonstructural replicase proteins in infected cells

FS Shi, Y Yu, YL Li, L Cui, Z Zhao, M Wang… - Microbiology …, 2022 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 is responsible for the COVID-
19 pandemic that has caused unprecedented loss of life and economic trouble all over the …

Role of heterocyclic compounds in SARS and SARS CoV-2 pandemic

M Negi, PA Chawla, A Faruk, V Chawla - Bioorganic Chemistry, 2020 - Elsevier
Coronaviruses have led to severe emergencies in the world since the outbreak of SARS
CoV in 2002, followed by MERS CoV in 2012. SARS CoV-2, the novel pandemic caused by …

A computational approach to aid clinicians in selecting anti-viral drugs for COVID-19 trials

A Mongia, SK Saha, E Chouzenoux, A Majumdar - Scientific reports, 2021 - nature.com
The year 2020 witnessed a heavy death toll due to COVID-19, calling for a global
emergency. The continuous ongoing research and clinical trials paved the way for vaccines …

[HTML][HTML] Trigonella foenum-graecum (fenugreek) differentially regulates antioxidant potential, photosynthetic, and metabolic activities under arsenic stress

J Ahmad, MA Beg, AA Ali, AA Al-Huqail… - … and Environmental Safety, 2022 - Elsevier
Arsenic (As) contamination is continuously increasing in the groundwaters and soils around
the world causing toxicity in the plants with a detrimental effect on physiology, growth, and …

Repurposing of gastric cancer drugs against COVID-19

C Sonkar, PK Doharey, AS Rathore, V Singh… - Computers in Biology …, 2021 - Elsevier
Abstract Corona Virus Disease 2019 (COVID-19) caused by Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) has become a global pandemic. Additionally, the …

Efficacy and safety of sofosbuvir/velpatasvir versus the standard of care in adults hospitalized with COVID-19: a single-centre, randomized controlled trial

B Sayad, R Khodarahmi, F Najafi… - Journal of …, 2021 - academic.oup.com
Objectives Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible
for the COVID-19 pandemic. The majority of patients experience asymptomatic to mild self …

Druggable targets from coronaviruses for designing new antiviral drugs

LR Silva, PF da Silva Santos-Junior… - Bioorganic & Medicinal …, 2020 - Elsevier
Severe respiratory infections were highlighted in the SARS-CoV outbreak in 2002, as well
as MERS-CoV, in 2012. Recently, the novel CoV (COVID-19) has led to severe respiratory …

Combined transcriptomics and in-silico approach uncovers the role of prognostic biomarkers in hepatocellular carcinoma

R Solanki, P Singh, MA Beg, R Dohare, AK Verma… - Human Gene, 2023 - Elsevier
Liver cancer is among the top five death-causing malignancies. High mortality rate, poor
prognosis, and minimal drug options for hepatocellular carcinoma (HCC) patients led to the …