Metabolic regulation of dendritic cell differentiation
Z He, X Zhu, Z Shi, T Wu, L Wu - Frontiers in Immunology, 2019 - frontiersin.org
Dendritic cells (DCs) are important antigen-presenting cells (APCs) that play essential roles
in bridging innate and adaptive immune responses. Differentiation stages of DC subsets …
in bridging innate and adaptive immune responses. Differentiation stages of DC subsets …
Regulation of monocyte differentiation by specific signaling modules and associated transcription factor networks
R Huber, D Pietsch, J Günther, B Welz, N Vogt… - Cellular and molecular …, 2014 - Springer
Monocyte/macrophages are important players in orchestrating the immune response as well
as connecting innate and adaptive immunity. Myelopoiesis and monopoiesis are …
as connecting innate and adaptive immunity. Myelopoiesis and monopoiesis are …
Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis
Transforming growth factor-β1 (TGF-β1) is a fundamental regulator of immune cell
development and function. In this study, we investigated the effects of TGF-β1 on the …
development and function. In this study, we investigated the effects of TGF-β1 on the …
PU. 1 suppresses Th2 cytokine expression via silencing of GATA3 transcription in dendritic cells
T Yashiro, M Kubo, H Ogawa, K Okumura… - PLoS …, 2015 - journals.plos.org
The transcription factor PU. 1 is predominantly expressed in dendritic cells (DCs) and is
essential for DC differentiation. Although there are several reports that PU. 1 positively …
essential for DC differentiation. Although there are several reports that PU. 1 positively …
miR-181a modulation of ERK-MAPK signaling sustains DC-SIGN expression and limits activation of monocyte-derived dendritic cells
DC-SIGN+ monocyte-derived dendritic cells (mo-DCs) play important roles in bacterial
infections and inflammatory diseases, but the factors regulating their differentiation and …
infections and inflammatory diseases, but the factors regulating their differentiation and …
[HTML][HTML] Human skin dendritic cell fate is differentially regulated by the monocyte identity factor Kruppel-like factor 4 during steady state and inflammation
J Jurkin, C Krump, R Köffel, C Fieber, C Schuster… - Journal of Allergy and …, 2017 - Elsevier
Background Langerhans cell (LC) networks play key roles in immunity and tolerance at body
surfaces. LCs are established prenatally and can be replenished from blood monocytes …
surfaces. LCs are established prenatally and can be replenished from blood monocytes …
GATA1 controls numbers of hematopoietic progenitors and their response to autoimmune neuroinflammation
D Hwang, LLW Ishikawa, MS Seyedsadr… - Blood …, 2022 - ashpublications.org
Abstract GATA-binding factor 1 (GATA1) is a transcription factor that governs the
development and function of multiple hematopoietic cell lineages. GATA1 is expressed in …
development and function of multiple hematopoietic cell lineages. GATA1 is expressed in …
[HTML][HTML] Identification of TROP2 (TACSTD2), an EpCAM-like molecule, as a specific marker for TGF-β1-dependent human epidermal Langerhans cells
Langerin (CD207) expression is a hallmark of epidermal Langerhans cells (LCs); however,
CD207+ cells comprise several functional subsets. Murine studies showed that epidermal …
CD207+ cells comprise several functional subsets. Murine studies showed that epidermal …
[HTML][HTML] β-Catenin promotes the differentiation of epidermal Langerhans dendritic cells
N Yasmin, S Konradi, G Eisenwort, YM Schichl… - Journal of Investigative …, 2013 - Elsevier
The epithelial signaling protein and transcriptional regulator β-catenin has recently been
implicated in hematopoietic dendritic cell (DC) differentiation as well as in DC-mediated …
implicated in hematopoietic dendritic cell (DC) differentiation as well as in DC-mediated …
The Human C‐Type Lectin‐Like Receptor CLEC‐1 is Upregulated by TGF‐β and Primarily Localized in the Endoplasmic Membrane Compartment
S Sattler, D Reiche, C Sturtzel, I Karas… - Scandinavian …, 2012 - Wiley Online Library
The orphan receptor CLEC‐1 is part of a subfamily of C‐type lectin‐like receptors, which is
encoded in the human natural killer gene complex and comprises several pattern …
encoded in the human natural killer gene complex and comprises several pattern …