In the mammalian heart, Ca2+‐independent, depolarization‐activated potassium (K+)
currents contribute importantly to shaping the waveforms of action potentials, and several …

Genetic approaches have succeeded in defining the molecular basis of an increasing array
of heart diseases, such as hypertrophic cardiomyopathy and the long-QT syndromes …

Abstract VOLTAGE-GATED potassium (K+) channels display a wide variety of conductances
and gating properties in vivo 1–3. This diversity can be attributed not only to the presence of …

Serôdio, Paulo and Bernardo Rudy. Differential expression of Kv4 K+ channel subunits
mediating subthreshold transient K+ (A-type) currents in rat brain. J. Neurophysiol. 79: 1081 …

The expression of 15 different K+ channels in canine heart was examined, and a new K+
channel gene (Kv4. 3), which encodes a rapidly inactivating K+ current, is described. The …

HERG, the human ether-a-go-go–related gene, encodes a K+-selective channel with
properties similar to the rapidly activating component of the delayed rectifier K+ current (I Kr) …

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS)
characterized by demyelination, with a relative sparing of axons. In MS patients, many …

A WIDE variety of voltage-gated K+ channels are involved in the regulation of neuronal
excitability and synaptic transmission. Their heterogeneity arises in part from the large …

Several cloned K+ channel subunits are candidates to underlie macroscopic currents in the
human heart, but direct evidence bearing on their role is lacking. The Kv1. 5 K+ channel …

1. Outward currents were studied in myocytes isolated from human atrial and subepicardial
ventricular myocardium using the whole‐cell voltage clamp technique at 22 degrees C. The …