Glucocorticoid resistance or insensitivity is a major barrier to the treatment of several
common inflammatory diseases—including chronic obstructive pulmonary disease and …

Since their establishment thirty years ago, THP-1 cells have become one of most widely
used cell lines to investigate the function and regulation of monocytes and macrophages in …

Parthanatos-associated apoptosis-inducing factor (AIF) nuclease (PAAN), also known as
macrophage migration inhibitor factor (MIF), is a member of the PD-D/E (X) K nucleases that …

INTRODUCTION Poly (ADP-ribose)(PAR) polymerase-1 (PARP-1) is a nuclear enzyme
responding to oxidative stress and DNA damage. Excessive activation of PARP-1 causes an …

Sepsis is a major health problem. The concept that sepsis mortality is the result of an
uncontrolled hyperinflammatory host response has recently been challenged. It is now …

抄録 Peroxiredoxins possess thioredoxin or glutathione peroxidase and chaperone-like
activities and thereby protect cells from oxidative insults. Recent studies, however, reveal …

Introduction: Macrophage migration inhibitory factor (MIF) has emerged as a promising drug
target in diseases including sepsis, rheumatoid arthritis, and cancer. MIF has multiple …

Produced by many cell types, macrophage migration inhibitory factor (MIF) is a pleiotropic
cytokine with critical and supporting roles in many disease states and conditions. Its disease …

Although acute lung injury (ALI) is an important problem in humans, its pathogenesis is
poorly understood. Airway instillation of bacterial LPS, a known complement activator …

Glucocorticoids (GCs) are the most potent anti-inflammatory agents known. A major factor
limiting their clinical use is the wide variation in responsiveness to therapy. The high doses …