Antimicrobial resistance threatens a resurgence of life-threatening bacterial infections and
the potential demise of many aspects of modern medicine. Despite intensive drug discovery …

A synthetic lethal interaction occurs between two genes when the perturbation of either gene
alone is viable but the perturbation of both genes simultaneously results in the loss of …

The spread of antimicrobial resistance has become a serious public health concern, making
once-treatable diseases deadly again and undermining the achievements of modern …

Large structural variations (SVs) within genomes are more challenging to identify than
smaller genetic variants but may substantially contribute to phenotypic diversity and …

A central goal of systems biology is to elucidate the structural and functional architecture of
the cell. To this end, large and complex networks of molecular interactions are being rapidly …

To determine whether genes retain ancestral functions over a billion years of evolution and
to identify principles of deep evolutionary divergence, we replaced 414 essential yeast …

The fission yeast Schizosaccharomyces pombe is an important model organism for the study
of eukaryotic molecular and cellular biology. Studies of S. pombe, together with studies of its …

From a preeminent researcher, this book looks at the key role of joint attention in both typical
and atypical development. Peter C. Mundy shows that no other symptom dimension is more …

Genetic interaction (GI) maps, comprising pairwise measures of how strongly the function of
one gene depends on the presence of a second, have enabled the systematic exploration of …

To what extent can variation in phenotypic traits such as disease risk be accurately predicted
in individuals? In this Review, I highlight recent studies in model organisms that are relevant …