An appropriate control over cell cycle progression depends on many factors. Cyclin-
dependent kinase (CDK) inhibitor p21 (also known as p21 WAF1/Cip1) is one of these …

A phenotype of indefinite growth arrest acquired in response to sublethal damage, cellular
senescence affects normal aging and age-related disease. Mitogen-activated protein …

The cell cycle inhibitor p21 CDKN1A is a protein playing multiple roles not only in the DNA
damage response, but also in many cellular processes during unperturbed cell growth. The …

Cell cycle progression is a tightly controlled fundamental process in living cells, with any
defects being closely linked to various abnormalities. The tumor suppressor p53/p21 axis is …

The final stage of cell division (mitosis), involves the compaction of the duplicated genome
into chromatid pairs. Each pair is captured by microtubules emanating from opposite spindle …

Background High dose ionizing radiation (IR) induces potent toxic cell effects mediated by
either direct DNA damage or the production of reactive oxygen species (ROS). IR-induced …

Abstract Neurogenic differentiation factor 1 (NeuroD1) is a transcription factor critical for
promoting neuronal differentiation and maturation. NeuroD1 is involved in neuroblastoma …

Aging, as a complex biological process, is accompanied by the accumulation of functional
loses at different levels, which makes age to be the biggest risk factor to many neurological …

The target of EGR1 protein 1 (TOE1) is evolutionarily conserved from Caenorhabditis
elegans to mammals, which plays a critical role in the maturation of a variety of small nuclear …

While the over-expression of tumor suppressor programmed cell death 4 (PDCD4) induces
apoptosis, it was recently shown that PDCD4 knockdown also induced apoptosis. In this …