The i-motif as a molecular target: more than a complementary DNA secondary structure
SL Brown, S Kendrick - Pharmaceuticals, 2021 - mdpi.com
Stretches of cytosine-rich DNA are capable of adopting a dynamic secondary structure, the i-
motif. When within promoter regions, the i-motif has the potential to act as a molecular switch …
motif. When within promoter regions, the i-motif has the potential to act as a molecular switch …
Stability and context of intercalated motifs (i-motifs) for biological applications
DNA is naturally dynamic and can self-assemble into alternative secondary structures
including the intercalated motif (i-motif), a four-stranded structure formed in cytosine-rich …
including the intercalated motif (i-motif), a four-stranded structure formed in cytosine-rich …
Redox-dependent control of i-Motif DNA structure using copper cations
MAS Abdelhamid, L Fábián… - Nucleic Acids …, 2018 - academic.oup.com
Previous computational studies have shown that Cu+ can act as a substitute for H+ to
support formation of cytosine (C) dimers with similar conformation to the hemi-protonated …
support formation of cytosine (C) dimers with similar conformation to the hemi-protonated …
From direct to indirect lithium targets: a comprehensive review of omics data
M Roux, A Dosseto - Metallomics, 2017 - academic.oup.com
Metal ions are critical to a wide range of biological processes. Among them, lithium (Li) has
been recognised for its benefit as a treatment for bipolar disorder (BD). However, we are yet …
been recognised for its benefit as a treatment for bipolar disorder (BD). However, we are yet …
In situ formation of transcriptional modulators using non-canonical DNA i-motifs
Non-canonical DNA i-motifs and G-quadruplexes are postulated as genetic switches for the
transcriptional regulation of proto-oncogenes. However, in comparison to G-quadruplexes …
transcriptional regulation of proto-oncogenes. However, in comparison to G-quadruplexes …
Two opposing effects of monovalent cations on the stability of i-motif structure
At acidic pH, cytosine-rich single-stranded DNA can be folded into a tetraplex structure
called i-motif (iM). In recent studies, the effect of monovalent cations on the stability of iM …
called i-motif (iM). In recent studies, the effect of monovalent cations on the stability of iM …
Opposite effects of potassium ions on the thermal stability of i-motif DNA in different buffer systems
B Gao, XM Hou - ACS omega, 2021 - ACS Publications
i-motifs are noncanonical DNA structures formed via the stack of intercalating hemi-
protonated C+: C base pairs in C-rich DNA strands and play essential roles in the regulation …
protonated C+: C base pairs in C-rich DNA strands and play essential roles in the regulation …
The Molecular Tête‐à‐Tête between G‐Quadruplexes and the i‐motif in the Human Genome
P Sengupta, D Bose, S Chatterjee - ChemBioChem, 2021 - Wiley Online Library
G‐Quadruplex (GQ) and i‐motif structures are the paradigmatic examples of nonclassical
tetrastranded nucleic acids having multifarious biological functions and widespread …
tetrastranded nucleic acids having multifarious biological functions and widespread …
i-Motif DNA: identification, formation, and cellular functions
S Tao, Y Run, D Monchaud, W Zhang - Trends in Genetics, 2024 - Elsevier
An i-motif (iM) is a four-stranded (quadruplex) DNA structure that folds from cytosine (C)-rich
sequences. iMs can fold under many different conditions in vitro, which paves the way for …
sequences. iMs can fold under many different conditions in vitro, which paves the way for …
Remodeling the conformational dynamics of I-motif DNA by helicases in ATP-independent mode at acidic environment
B Gao, YT Zheng, AM Su, B Sun, XG Xi, XM Hou - Iscience, 2022 - cell.com
I-motifs are noncanonical four-stranded DNA structures formed by C-rich sequences at
acidic environment with critical biofunctions. The particular pH sensitivity has inspired the …
acidic environment with critical biofunctions. The particular pH sensitivity has inspired the …