Variability of hepatitis C virus

P Simmonds - Hepatology, 1995 - journals.lww.com
The discovery and characterization of the main causative agent of non-A, non-B hepatitis
(NANBH) represent a major success in the application of cloning techniques in the …

Hepatitis C virus replication in mice with chimeric human livers

DF Mercer, DE Schiller, JF Elliott, DN Douglas, C Hao… - Nature medicine, 2001 - nature.com
Lack of a small animal model of the human hepatitis C virus (HCV) has impeded
development of antiviral therapies against this epidemic infection. By transplanting normal …

Investigation of the pattern of hepatitis C virus sequence diversity in different geographical regions: implications for virus classification

J Mellor, EC Holmes, LM Jarvis… - Journal of General …, 1995 - microbiologyresearch.org
Genotypes of hepatitis C virus (HCV) present within 104 samples from HCV-infected
individuals from Africa, the Middle East, the Indian subcontinent and South-East Asia were …

Survey of major genotypes and subtypes of hepatitis C virus using RFLP of sequences amplified from the 5′ non-coding region

F Davidson, P Simmonds… - Journal of General …, 1995 - microbiologyresearch.org
A method is described for identifying different genotypes of hepatitis C virus (HCV) by
restriction endonuclease cleavage of sequences amplified by PCR from the 5′ non-coding …

Hepatitis C virus: biological and clinical consequences of genetic heterogeneity

MP Cooreman… - Scandinavian Journal …, 1996 - Taylor & Francis
Hepatitis C Virus infection accounts for the majority of post-transfusion and sporadic
hepatitis. In Western Europe, anti-HCV is detected in 0.4–1.5% of healthy blood donors …

[HTML][HTML] Study of a novel hypervariable region in hepatitis C virus (HCV) E2 envelope glycoprotein

M Troesch, I Meunier, P Lapierre, N Lapointe, F Alvarez… - Virology, 2006 - Elsevier
A large share of hepatitis C virus amino acid sequence variation is concentrated within two
hypervariable regions located at the N-terminus of the E2 envelope glycoprotein (HVR1 and …

Frequent reinfection and reactivation of hepatitis C virus genotypes in multitransfused hemophiliacs

LM Jarvis, HG Watson, F McOmish… - Journal of Infectious …, 1994 - academic.oup.com
The frequency and dynamics of infection with different genotypes of hepatitis C virus were
investigated in a cohort of hemophiliacs repeatedly exposed to non-virus-inactivated clotting …

Hepatitis C genotypes in Finland determined by RFLP

P Pohjanpelto, M Lappalainen, A Widell… - Clinical and diagnostic …, 1996 - Elsevier
Genotyping of hepatitis C virus (HCV) is important because of its clinical and
epidemiological implications. We report here the distribution of HCV genotypes in various …

Identification of numerous hepatitis C virus genotypes in Montreal, Canada

L Bernier, B Willems, G Delage… - Journal of clinical …, 1996 - Am Soc Microbiol
Hepatitis C virus genotypes were determined for 358 viremic individuals in Montreal,
Canada, by restriction endonuclease analysis of PCR products and phylogenetic analysis of …

Heterogeneity of hepatitis C virus genotypes in hemophilia: relationship with chronic liver disease

FE Preston, LM Jarvis, M Makris, L Philp… - 1995 - ashpublications.org
In this study we have determined the hepatitis C virus (HCV) serotype and genotype in a
cohort of 96 HCV-infected hemophiliacs and have examined the relationship between HCV …