Radiation-induced fibrosis in patients with head and neck cancer: a review of pathogenesis and clinical outcomes

P Ramia, L Bodgi, D Mahmoud… - Clinical Medicine …, 2022 - journals.sagepub.com
Radiotherapy-related fibrosis remains one of the most challenging treatment related side
effects encountered by patients with head and neck cancer. Several established and …

Can intensity-modulated-radiotherapy reduce toxicity in head and neck squamous cell carcinoma?

J Van der Veen, S Nuyts - Cancers, 2017 - mdpi.com
Intensity modulated radiotherapy (IMRT) is a modern radiotherapy technique that was
implemented in the mid-1990s. It allows closer shaping of dose, to target volumes, thereby …

Targets for protection and mitigation of radiation injury

E Khodamoradi, M Hoseini-Ghahfarokhi… - Cellular and Molecular …, 2020 - Springer
Protection of normal tissues against toxic effects of ionizing radiation is a critical issue in
clinical and environmental radiobiology. Investigations in recent decades have suggested …

A randomized trial (RAREST-01) comparing Mepitel® Film and standard care for prevention of radiation dermatitis in patients irradiated for locally advanced …

D Rades, CA Narvaez, L Splettstößer, C Dömer… - Radiotherapy and …, 2019 - Elsevier
Abstract Mepitel® Film (MEP) and standard care (STD) were compared for radiation
dermatitis in SCCHN patients. This trial was stopped prematurely since13/28 patients did not …

Impact of clustering oral symptoms in the pathogenesis of radiation caries: a systematic review

AF Gouvea Vasconcellos, NR Palmier, ACP Ribeiro… - Caries …, 2020 - karger.com
Radiation-related caries (RRC) is a disease with a high potential for destruction of the
dentition, which impairs quality of life in head-and-neck (HN) cancer (HNC) patients who …

Pravastatin reverses established radiation-induced cutaneous and subcutaneous fibrosis in patients with head and neck cancer: results of the biology-driven phase 2 …

C Bourgier, A Auperin, S Rivera, P Boisselier… - International Journal of …, 2019 - Elsevier
Purpose The “PRAVACUR” phase 2 trial (NCT01268202) assessed the efficacy of
pravastatin as an antifibrotic agent in patients with established cutaneous and subcutaneous …

The neck burn scar contracture: a concept of effective treatment

S Akita, K Hayashida, S Takaki, Y Kawakami… - Burns & …, 2017 - academic.oup.com
A neck scar contracture can severely and negatively affect the function of mastication,
phonic, or breathing and result in neck pain and issues with esthetics. The best way is of …

Radiation-induced skin injury in the head and neck region: pathogenesis, clinics, prevention, treatment considerations and proposal for management algorithm

J Pazdrowski, J Gornowicz-Porowska… - Reports of Practical …, 2024 - journals.viamedica.pl
Worldwide increase o fh ead and neck cancers ranks thes em alignancies among top
causes of cancer i nh uman population. Radiation induced skin injury (RISI) is one of th em …

Skin DVHs predict cutaneous toxicity in Head and Neck Cancer patients treated with Tomotherapy

M Mori, GM Cattaneo, I Dell'Oca, S Foti, R Calandrino… - Physica Medica, 2019 - Elsevier
Purpose To explore the association between planning skin dose-volume data and acute
cutaneous toxicity after Radio–chemotherapy for Head and Neck (HN) cancer patients …

Three-dimensional conformal radiotherapy versus intensity modulated radiotherapy with simultaneous integrated boost in the treatment of locally advanced head and …

M Jirkovska, T Novak, B Malinova, R Lohynska - Neoplasma, 2019 - search.ebscohost.com
The treatment of locally advanced head and neck cancer (LAHNC) requires a multimodality
approach. Radiotherapy with combination of chemotherapy are demonstrated to be …