Iron overload in alcoholic liver disease: underlying mechanisms, detrimental effects, and potential therapeutic targets

LX Li, FF Guo, H Liu, T Zeng - Cellular and Molecular Life Sciences, 2022 - Springer
Alcoholic liver disease (ALD) is a global public health challenge due to the high incidence
and lack of effective therapeutics. Evidence from animal studies and ALD patients has …

Abnormal metabolic processes involved in the pathogenesis of non‑alcoholic fatty liver disease

M Shao, Z Ye, Y Qin, T Wu - Experimental and …, 2020 - spandidos-publications.com
Non‑alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases
and can lead to liver cirrhosis or liver cancer in severe cases. In recent years, the incidence …

Role of serum uric acid and ferritin in the development and progression of NAFLD

R Lombardi, G Pisano, S Fargion - International journal of molecular …, 2016 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD), tightly linked to the metabolic syndrome (MS), has
emerged as a leading cause of chronic liver disease worldwide. Since it is potentially …

Icariin supplementation suppresses the markers of ferroptosis and attenuates the progression of nonalcoholic steatohepatitis in mice fed a methionine choline …

J Choi, H Choi, J Chung - International Journal of Molecular Sciences, 2023 - mdpi.com
Icariin, a flavonoid abundant in the herb Epimedium, exhibits anti-ferroptotic activity.
However, its impact on nonalcoholic steatohepatitis (NASH) development remains unclear …

Iron activates cGAS-STING signaling and promotes hepatic inflammation

H Li, L Hu, L Wang, Y Wang, M Shao… - Journal of Agricultural …, 2022 - ACS Publications
Iron deposition and chronic inflammation are associated with chronic liver diseases, such as
alcoholic liver disease, nonalcoholic fatty liver disease, and chronic hepatitis B and C …

Soluble Hemojuvelin and Ferritin: Potential Prognostic Markers in Pediatric Hematopoietic Cell Transplantation

J Styczyński, A Słomka, M Łęcka, K Albrecht… - Cancers, 2023 - mdpi.com
Simple Summary In children after intensive chemotherapy for acute leukemias (AL) or
undergoing hematopoietic cell transplantation (HCT), the prognostic impact of 12 serum iron …

AGER1 deficiency-triggered ferroptosis drives fibrosis progression in nonalcoholic steatohepatitis with type 2 diabetes mellitus

Y Gong, Z Liu, Y Zhang, J Zhang, Y Zheng, Z Wu - Cell Death Discovery, 2023 - nature.com
Hyperglycemia is an independent risk factor for the rapid progression of nonalcoholic
steatohepatitis (NASH) to liver fibrosis with an incompletely defined mechanism. Ferroptosis …

Chronic exposure to MC-LR increases the risks of microcytic anemia: Evidence from human and mice

C Pan, M Yan, H Jin, H Guo, X Han - Environmental pollution, 2021 - Elsevier
Microcystins (MCs) produced by cyanobacteria are potent toxins to humans that cannot be
ignored. However, the toxicity of MCs to humans remains largely unknown. The study …

Hyperferritinemia in nonalcoholic fatty liver disease: iron accumulation or inflammation?

W Moris, P Verhaegh, D Jonkers… - Seminars in Liver …, 2019 - thieme-connect.com
Hyperferritinemia, observed in inflammation, iron overload as well as in combination of both,
is found in∼ 30% of nonalcoholic fatty liver disease (NAFLD) patients. The authors …

Serum cytokines, adipokines and ferritin for non-invasive assessment of liver fibrosis in chronic liver disease: a systematic review

SM Haghgoo, H Sharafi, SM Alavian - Clinical Chemistry and …, 2019 - degruyter.com
Chronic liver disease (CLD) is a major health problem worldwide. Non-alcoholic fatty liver
disease (NAFLD), chronic hepatitis C (CHC), chronic hepatitis B (CHB), and alcoholic liver …