Stress granules (SGs) are membraneless cell compartments formed in response to different
stress stimuli, wherein translation factors, mRNAs, RNA-binding proteins (RBPs) and other …

Significant research efforts are ongoing to elucidate the complex molecular mechanisms
underlying amyotrophic lateral sclerosis (ALS), which may in turn pinpoint potential …

Mitochondria have their own DNA (mtDNA), which is susceptible to the accumulation of
disease-causing mutations. To prevent deleterious mutations from being inherited, the …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with the progressive
loss of motor neurons, leading to a fatal paralysis. According to whether there is a family …

Yeast ataxin-2, also known as Pbp1 (polyA binding protein-binding protein 1), is an
intrinsically disordered protein implicated in stress granule formation, RNA biology, and …

Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant cerebellar ataxia that
occurs as a consequence of abnormal CAG expansions in the ATXN2 gene. Progressive …

The underlying genetic and molecular mechanisms that drive amyotrophic lateral sclerosis
(ALS) remain poorly understood. Structural variants within the genome can play a significant …

In response to different stress stimuli, cells transiently form stress granules (SGs) in order to
protect themselves and re-establish homeostasis. Besides these important cellular functions …

RNA-binding proteins play fundamental roles in the regulation of molecular processes
critical to cellular and organismal homeostasis. Recent studies have identified the RNA …

Polyglutamine diseases are a group of neurodegenerative disorders caused by an
abnormal expansion of CAG repeat tracts in the codifying regions of nine, otherwise …