Exosome engineering in cell therapy and drug delivery

S Sadeghi, FR Tehrani, S Tahmasebi, A Shafiee… - …, 2023 - Springer
Cell-derived exosomes have opened new horizons in modern therapy for advanced drug
delivery and therapeutic applications, due to their key features such as low immunogenicity …

Clinical trials with mesenchymal stem cell therapies for osteoarthritis: challenges in the regeneration of articular cartilage

DC Carneiro, LT Araújo, GC Santos… - International Journal of …, 2023 - mdpi.com
Osteoarthritis (OA) is a whole-joint disease primarily characterized by the deterioration of
hyaline cartilage. Current treatments include microfracture and chondrocyte implantation as …

Therapeutic mesenchymal stem/stromal cells: value, challenges and optimization

M Najar, R Melki, F Khalife, L Lagneaux… - Frontiers in cell and …, 2022 - frontiersin.org
Cellular therapy aims to replace damaged resident cells by restoring cellular and molecular
environments suitable for tissue repair and regeneration. Among several candidates …

Recent progress in the manipulation of biochemical and biophysical cues for engineering functional tissues

B Bakhshandeh, N Ranjbar, A Abbasi… - Bioengineering & …, 2023 - Wiley Online Library
Tissue engineering (TE) is currently considered a cutting‐edge discipline that offers the
potential for developing treatments for health conditions that negatively affect the quality of …

Research progress of engineered mesenchymal stem cells and their derived exosomes and their application in autoimmune/inflammatory diseases

X Zhu, D Ma, B Yang, Q An, J Zhao, X Gao… - Stem cell research & …, 2023 - Springer
Autoimmune/inflammatory diseases affect many people and are an important cause of
global incidence and mortality. Mesenchymal stem cells (MSCs) have low immunogenicity …

[HTML][HTML] CRISPR/Cas9-engineered mesenchymal stromal/stem cells and their extracellular vesicles: A new approach to overcoming cell therapy limitations

A Hazrati, K Malekpour, S Soudi… - Biomedicine & …, 2022 - Elsevier
Cell therapy is one of the newest therapeutic approaches for treating tissue destruction
diseases and replacing damaged parts in defective tissues. Among different cells …

How can clinical safety and efficacy concerns in stem cell therapy for spinal cord injury be overcome?

N Hejrati, R Wong, M Khazaei… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Spinal cord injury (SCI) can lead to severe neurological dysfunction. Despite
scientific and medical advances, clinically effective regenerative therapies including stem …

Multipotent mesenchymal stem cell-based therapies for spinal cord injury: current progress and future prospects

CW Zeng - Biology, 2023 - mdpi.com
Simple Summary Mesenchymal stem cells (MSCs) are a promising option for developing
new treatments for spinal cord injury (SCI). They can help repair damaged tissue, making …

Electro‐acupuncture and its combination with adult stem cell transplantation for spinal cord injury treatment: A summary of current laboratory findings and a review of …

YS Zeng, Y Ding, HY Xu, X Zeng… - CNS Neuroscience …, 2022 - Wiley Online Library
The incidence and disability rate of spinal cord injury (SCI) worldwide are high, imposing a
heavy burden on patients. Considerable research efforts have been directed toward …

Extracellular vesicles and their cells of origin: Open issues in autoimmune diseases

A Haghighitalab, M Dominici, MM Matin… - Frontiers in …, 2023 - frontiersin.org
The conventional therapeutic approaches to treat autoimmune diseases through
suppressing the immune system, such as steroidal and non-steroidal anti-inflammatory …