Alzheimer's disease (AD) is the most frequent cause of dementia. After decades of research,
we know the importance of the accumulation of protein aggregates such as β-amyloid …

Phosphatidic acid (PA) is a simple glycerophospholipid with a well-established role as an
intermediate in phospholipid biosynthesis. In addition to its role in lipid biosynthesis, PA has …

Abstract Apolipoprotein E ε4 (APOE4) is the primary genetic risk factor for the late-onset form
of Alzheimer's disease (AD). Although the reason for this association is not completely …

Mitochondrial dysfunction and subsequent metabolic deregulation is observed in
neurodegenerative diseases and aging. Mutations in the presenilin (PSEN) encoding genes …

Life expectancy in Western countries is increasing, with concomitant rise in ageing-related
pathologies, including Parkinson's and Alzheimer's disease, as well as other …

Phospholipase D (PLD) is an enzyme that consists of six isoforms (PLD1–PLD6) and has
been discovered in different organisms including bacteria, viruses, plants, and mammals …

Phosphatidic acid (PA) is a signaling lipid involved in the modulation of synaptic structure
and functioning. Based on previous work showing a decreasing PA gradient along the …

Phospholipase D (PLD) hydrolyses phosphatidylcholine (PtdCho) to produce free choline
and the critically important lipid signaling molecule phosphatidic acid (PtdOH). Since the …

This study aimed to investigate the effect of long-term aerobic exercise on the metabolism of
intestinal contents in APP/PS1 mice was studied using a non-targeted metabolomics …

Human sepiapterin reductase (SR) deficiency is an inherited disease caused by SPR gene
mutations and is a monoamine neurotransmitter disorder. Here, we investigated whether the …