Tumor necrosis factor-related apoptosis-inducing ligand or Apo 2 ligand (TRAIL/Apo2L) is a
member of the tumor necrosis factor (TNF) family of ligands capable of initiating apoptosis …

Breast cancer (BC) affects over 250,000 women in the US each year. Drug-resistant cancer
cells are responsible for most breast cancer fatalities. Scientists are developing novel …

Apo2 ligand or tumor necrosis factor (TNF)-related apoptosis-inducing ligand (Apo2L/TRAIL)
is one of several members of the TNF gene superfamily that induce apoptosis through …

Targeted therapy for metastatic diseases relies on the identification of functionally important
metastasis genes from a large number of random genetic alterations. Here we use a …

Telomerase activation is a critical step for human carcinogenesis through the maintenance
of telomeres, but the activation mechanism during carcinogenesis remains unclear …

Background and aims: Hepatitis B virus (HBV) DNA integration into or close to cellular
genes is frequently detected in HBV positive hepatocellular carcinomas (HCC). We have …

Killing of tumor cells by anticancer therapies commonly used in the treatment of cancer, eg
chemotherapy, γ-irradiation, immunotherapy or suicide gene therapy, is predominantly …

Abstract hTERT is the catalytic subunit of the telomerase and is hence required for
telomerase maintenance activity and cancer cell immortalization. Here, we show that acute …

Apoptosis is a source of much research interest across many fields, including developmental
biology, immunology and oncology. As the exact pathways of this process are identified, so …

We have constructed a new capsid-modified adenovirus (Ad) vector that specifically
replicates in tumor cells and expresses TNF-related apoptosis-inducing ligand (TRAIL). The …