The relation between PI3K/AKT signalling pathway and cancer
Abstract Phosphatidylinositol 3-kinases (PI3Ks) are crucial coordinators of intracellular
signalling in response to the extracellular stimulators. Hyperactivation of PI3K signalling …
signalling in response to the extracellular stimulators. Hyperactivation of PI3K signalling …
PIK3CA in cancer: The past 30 years
Almost thirty years ago, PI3K was discovered as a lipid kinase associated with certain
oncoproteins. The first decade of research on PI3K saw the identification, purification and …
oncoproteins. The first decade of research on PI3K saw the identification, purification and …
High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability
LWT Cheung, BT Hennessy, J Li, S Yu, AP Myers… - Cancer discovery, 2011 - AACR
We demonstrate that phosphatidylinositol 3-kinase (PI3K) pathway aberrations occur in>
80% of endometrioid endometrial cancers, with coordinate mutations of multiple PI3K …
80% of endometrioid endometrial cancers, with coordinate mutations of multiple PI3K …
Use of mutation profiles to refine the classification of endometrial carcinomas
The classification of endometrial carcinomas is based on pathological assessment of tumour
cell type; the different cell types (endometrioid, serous, carcinosarcoma, mixed …
cell type; the different cell types (endometrioid, serous, carcinosarcoma, mixed …
Oncogenic mutations of PIK3CA in human cancers
The involvement of the PIK3CA gene product p110α, the catalytic subunit of
phosphatidylinositol 3-kinase (PI3K), in human cancer has been suggested for over 15 …
phosphatidylinositol 3-kinase (PI3K), in human cancer has been suggested for over 15 …
Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer
H Liang, LWT Cheung, J Li, Z Ju, S Yu… - Genome …, 2012 - genome.cshlp.org
Endometrial cancer is the most common gynecological malignancy, with more than 280,000
cases occurring annually worldwide. Although previous studies have identified important …
cases occurring annually worldwide. Although previous studies have identified important …
[HTML][HTML] Loss of ARID1A protein expression occurs as an early event in ovarian clear-cell carcinoma development and frequently coexists with PIK3CA mutations
S Yamamoto, H Tsuda, M Takano, S Tamai… - Modern Pathology, 2012 - Elsevier
ARID1A is a recently identified tumor suppressor gene that is mutated in∼ 50% of ovarian
clear-cell carcinomas. This mutation is associated with loss of ARID1A protein expression as …
clear-cell carcinomas. This mutation is associated with loss of ARID1A protein expression as …
Molecular pathology of endometrial carcinoma
X Matias‐Guiu, J Prat - Histopathology, 2013 - Wiley Online Library
This review paper discusses the main molecular alterations of endometrial carcinoma, the
most common cancer of the female genital tract. Two clinicopathological variants are …
most common cancer of the female genital tract. Two clinicopathological variants are …
Profiling critical cancer gene mutations in clinical tumor samples
Background Detection of critical cancer gene mutations in clinical tumor specimens may
predict patient outcomes and inform treatment options; however, high-throughput mutation …
predict patient outcomes and inform treatment options; however, high-throughput mutation …
A Unique Spectrum of Somatic PIK3CA (p110α) Mutations Within Primary Endometrial Carcinomas
ML Rudd, JC Price, S Fogoros, AK Godwin… - Clinical cancer …, 2011 - AACR
Purpose: The goal of this study was to comprehensively define the incidence of mutations in
all exons of PIK3CA in both endometrioid endometrial cancer (EEC) and nonendometrioid …
all exons of PIK3CA in both endometrioid endometrial cancer (EEC) and nonendometrioid …