The far-reaching scope of neuroinflammation after traumatic brain injury

DW Simon, MJ McGeachy, H Bayır, RSB Clark… - Nature Reviews …, 2017 - nature.com
The'silent epidemic'of traumatic brain injury (TBI) has been placed in the spotlight as a result
of clinical investigations and popular press coverage of athletes and veterans with single or …

A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers

CR Jack Jr, DA Bennett, K Blennow, MC Carrillo… - Neurology, 2016 - AAN Enterprises
Biomarkers have become an essential component of Alzheimer disease (AD) research and
because of the pervasiveness of AD pathology in the elderly, the same biomarkers are used …

Iatrogenic Alzheimer's disease in recipients of cadaveric pituitary-derived growth hormone

G Banerjee, SF Farmer, H Hyare, Z Jaunmuktane… - Nature Medicine, 2024 - nature.com
Alzheimer's disease (AD) is characterized pathologically by amyloid-beta (Aβ) deposition in
brain parenchyma and blood vessels (as cerebral amyloid angiopathy (CAA)) and by …

The chronic and evolving neurological consequences of traumatic brain injury

L Wilson, W Stewart, K Dams-O'Connor… - The Lancet …, 2017 - thelancet.com
Traumatic brain injury (TBI) can have lifelong and dynamic effects on health and wellbeing.
Research on the long-term consequences emphasises that, for many patients, TBI should be …

Geriatric traumatic brain injury: epidemiology, outcomes, knowledge gaps, and future directions

RC Gardner, K Dams-O'Connor… - Journal of …, 2018 - liebertpub.com
This review of the literature on traumatic brain injury (TBI) in older adults focuses on incident
TBI sustained in older adulthood (“geriatric TBI”) rather than on the separate, but related …

Traumatic brain injuries

K Blennow, DL Brody, PM Kochanek, H Levin… - Nature reviews Disease …, 2016 - nature.com
Traumatic brain injuries (TBIs) are clinically grouped by severity: mild, moderate and severe.
Mild TBI (the least severe form) is synonymous with concussion and is typically caused by …

Severe traumatic brain injury: targeted management in the intensive care unit

N Stocchetti, M Carbonara, G Citerio, A Ercole… - The Lancet …, 2017 - thelancet.com
Severe traumatic brain injury (TBI) is currently managed in the intensive care unit with a
combined medical–surgical approach. Treatment aims to prevent additional brain damage …

Amyloid biomarkers in Alzheimer's disease

K Blennow, N Mattsson, M Schöll, O Hansson… - Trends in …, 2015 - cell.com
Aggregation of amyloid-β (Aβ) into oligomers, fibrils, and plaques is central in the molecular
pathogenesis of Alzheimer's disease (AD), and is the main focus of AD drug development …

Traumatic axonal injury: mechanisms and translational opportunities

CS Hill, MP Coleman, DK Menon - Trends in neurosciences, 2016 - cell.com
Traumatic axonal injury (TAI) is an important pathoanatomical subgroup of traumatic brain
injury (TBI) and a major driver of mortality and functional impairment. Experimental models …

The neuropathology of sport

AC McKee, DH Daneshvar, VE Alvarez, TD Stein - Acta neuropathologica, 2014 - Springer
The benefits of regular exercise, physical fitness and sports participation on cardiovascular
and brain health are undeniable. Physical activity reduces the risk for cardiovascular …