Cytokine signaling represents one of the cornerstones of the immune system, mediating the
complex responses required to facilitate appropriate immune cell development and function …

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterised by
infiltration of immune cells into the affected synovium, release of inflammatory cytokines and …

Background Despite unmet need, 15 years have passed since a topical therapy with a new
mechanism of action for atopic dermatitis (AD) has been approved. Janus kinase (JAK) …

There are four members of the JAK family and seven of the STAT family in mammals. The
JAK/STAT molecular pathway could be activated by broad hormones, cytokines, growth …

Recently, cancer has been considered to be a complex system that includes the tumor
microenvironment (TME). Tumor-associated macrophages (TAMs) are the most common …

One of the most frequent complications in patients with diabetes mellitus is diabetic
nephropathy (DN). At present, it constitutes the first cause of end stage renal disease, and …

Numerous nano-dimensioned materials have been generated as a result of several
advancements in nanoscale science such as metallic nanoparticles (mNPs) which have …

In evolutionary terms, GH and intracellular STAT 5 signaling is a very old regulatory system.
Whereas insulin dominates periprandially, GH may be viewed as the primary anabolic …

BDNF/TrkB neurotrophic signaling regulates neuronal development, differentiation, and
survival, and deficient BDNF/TrkB activity underlies neurodegeneration in Alzheimer's …

Background: Sepsis is a deadly immunological disorder and its pathophysiology is still
poorly understood. We aimed to determine if specific pro-inflammatory and anti-inflammatory …