While skeletal muscle remodeling happens throughout life, diseases that result in its
dysfunction are accountable for many deaths. Indeed, skeletal muscle is exceptionally …

Skeletal muscle (SM) pain and fatigue are common in Fabry disease (FD). Here, we
undertook the investigation of the energetic mechanisms related to FD-SM phenotype. A …

Background Duchenne muscular dystrophy (DMD) is a lethal muscle disease detected in
approximately 1: 5000 male births. DMD is caused by mutations in the DMD gene, encoding …

Background Muscular dystrophy (MD) causes muscle wasting and is often lethal in patients
due to a lack of proven therapies. In contrast, mouse models of MD are notoriously mild. We …

Background: Muscular dystrophies (MDs) are characterized by chronic muscle wasting but
also poorly understood metabolic co-morbidities. We have recently shown that Duchenne …

Although Duchenne muscular dystrophy (DMD) primarily affects muscle tissues, the
alterations to systemic metabolism manifested in DMD patients contribute to the severe …

Rodent models of Duchenne muscular dystrophy (DMD) often do not recapitulate the
severity of muscle wasting and resultant fibro‐fatty infiltration observed in DMD patients …

Limb-girdle muscular dystrophy (MD) type 2B (LGMD2B) and Duchenne MD (DMD) are
caused by mutations to the Dysferlin and Dystrophin genes, respectively. We have recently …

Aim Fibrosis is the most common complication from chronic diseases, and yet no therapy
capable of mitigating its effects is available. Our goal is to unveil specific signaling regulating …

Despite its notoriously mild phenotype, the dystrophin-deficient mdx mouse is the most
common model of Duchenne muscular dystrophy (DMD). By mimicking a human DMD …