Causes and consequences of snake venom variation
Snake venoms are mixtures of toxins that vary extensively between and within snake
species. This variability has serious consequences for the management of the world's 1.8 …
species. This variability has serious consequences for the management of the world's 1.8 …
Molecular mechanisms of adaptive evolution in wild animals and plants
Wild animals and plants have developed a variety of adaptive traits driven by adaptive
evolution, an important strategy for species survival and persistence. Uncovering the …
evolution, an important strategy for species survival and persistence. Uncovering the …
Phylogenetically diverse diets favor more complex venoms in North American pitvipers
ML Holding, JL Strickland… - Proceedings of the …, 2021 - National Acad Sciences
The role of natural selection in the evolution of trait complexity can be characterized by
testing hypothesized links between complex forms and their functions across species …
testing hypothesized links between complex forms and their functions across species …
Biogeographic venom variation in Russell's viper (Daboia russelii) and the preclinical inefficacy of antivenom therapy in snakebite hotspots
RR Senji Laxme, S Khochare, S Attarde… - PLoS neglected …, 2021 - journals.plos.org
Background Snakebite in India results in over 58,000 fatalities and a vast number of
morbidities annually. The majority of these clinically severe envenomings are attributed to …
morbidities annually. The majority of these clinically severe envenomings are attributed to …
Biogeographical venom variation in the Indian spectacled cobra (Naja naja) underscores the pressing need for pan-India efficacious snakebite therapy
RR Senji Laxme, S Attarde, S Khochare… - PLOS neglected …, 2021 - journals.plos.org
Background Snake venom composition is dictated by various ecological and environmental
factors, and can exhibit dramatic variation across geographically disparate populations of …
factors, and can exhibit dramatic variation across geographically disparate populations of …
Convergent evolution of toxin resistance in animals
Convergence is the phenomenon whereby similar phenotypes evolve independently in
different lineages. One example is resistance to toxins in animals. Toxins have evolved …
different lineages. One example is resistance to toxins in animals. Toxins have evolved …
The rise of genomics in snake venom research: recent advances and future perspectives
Snake venoms represent a danger to human health, but also a gold mine of bioactive
proteins that can be harnessed for drug discovery purposes. The evolution of snakes and …
proteins that can be harnessed for drug discovery purposes. The evolution of snakes and …
When one phenotype is not enough: divergent evolutionary trajectories govern venom variation in a widespread rattlesnake species
G Zancolli, JJ Calvete, MD Cardwell… - … of the Royal …, 2019 - royalsocietypublishing.org
Understanding the origin and maintenance of phenotypic variation, particularly across a
continuous spatial distribution, represents a key challenge in evolutionary biology. For this …
continuous spatial distribution, represents a key challenge in evolutionary biology. For this …
The Tiger Rattlesnake genome reveals a complex genotype underlying a simple venom phenotype
MJ Margres, RM Rautsaw… - Proceedings of the …, 2021 - National Acad Sciences
Variation in gene regulation is ubiquitous, yet identifying the mechanisms producing such
variation, especially for complex traits, is challenging. Snake venoms provide a model …
variation, especially for complex traits, is challenging. Snake venoms provide a model …
Snakes on a plain: biotic and abiotic factors determine venom compositional variation in a wide-ranging generalist rattlesnake
Background Snake venoms are trophic adaptations that represent an ideal model to
examine the evolutionary factors that shape polymorphic traits under strong natural …
examine the evolutionary factors that shape polymorphic traits under strong natural …