When a neuron breaks silence, it can emit action potentials in a number of patterns. Some
responses are so sudden and intense that electrophysiologists felt the need to single them …

The hippocampal mossy fiber synapse, formed between axons of dentate gyrus granule
cells and dendrites of CA3 pyramidal neurons, is a key synapse in the trisynaptic circuitry of …

Post-tetanic potentiation (PTP) is an attractive candidate mechanism for hippocampus-
dependent short-term memory. Although PTP has a uniquely large magnitude at …

The balance between fast synchronous and delayed asynchronous release of
neurotransmitters has a major role in defining computational properties of neuronal …

Adult-born granule neurons pass through immature critical periods where they display
enhanced somatic excitability and afferent plasticity, which is believed to endow them with …

Pattern separation is a fundamental brain computation that converts small differences in
input patterns into large differences in output patterns. Several synaptic mechanisms of …

Cyclic adenosine monophosphate (cAMP) is a crucial second messenger involved in both
pre-and postsynaptic plasticity in many neuronal types across species. In the hippocampal …

Neurotransmitter release is a highly controlled process by which synapses can critically
regulate information transfer within neural circuits. While presynaptic receptors–typically …

Short-term synaptic plasticity refers to the regulation of synapses by their past activity on time
scales of milliseconds to minutes. Hippocampal mossy fiber synapses onto CA3 pyramidal …

In the hippocampus, episodic memories are thought to be encoded by the formation of
ensembles of synaptically coupled CA3 pyramidal cells driven by sparse but powerful mossy …