Non-coding RNAs in human health and disease: potential function as biomarkers and therapeutic targets
T Loganathan, GP Doss C - Functional & integrative genomics, 2023 - Springer
Human diseases have been a critical threat from the beginning of human history. Knowing
the origin, course of action and treatment of any disease state is essential. A microscopic …
the origin, course of action and treatment of any disease state is essential. A microscopic …
Peptide nucleic acid (PNA) and its applications in chemical biology, diagnostics, and therapeutics
Peptide nucleic acid (PNA) stands as one of the most successful artificial oligonucleotide
mimetics. Salient features include the stability of hybridization complexes (either as …
mimetics. Salient features include the stability of hybridization complexes (either as …
Role of pirfenidone in TGF-β pathways and other inflammatory pathways in acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection: a theoretical …
SH Hamidi, S Kadamboor Veethil, SH Hamidi - Pharmacological Reports, 2021 - Springer
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
pulmonary injury or multiple-organ injury by various pathological pathways. Transforming …
pulmonary injury or multiple-organ injury by various pathological pathways. Transforming …
[HTML][HTML] Molecular basis of cystic fibrosis: from bench to bedside
MC Dechecchi, A Tamanini… - Annals of translational …, 2018 - ncbi.nlm.nih.gov
Cystic fibrosis (CF), is an autosomal recessive disease affecting different organs. The lung
disease, characterized by recurrent and chronic bacterial infection and inflammation since …
disease, characterized by recurrent and chronic bacterial infection and inflammation since …
MicroRNAs and long non-coding RNAs in genetic diseases
Since the discovery and classification of non-coding RNAs, their roles have gained great
attention. In this respect, microRNAs and long non-coding RNAs have been firmly …
attention. In this respect, microRNAs and long non-coding RNAs have been firmly …
[HTML][HTML] One size does not fit all: the past, present and future of cystic fibrosis causal therapies
MM Ensinck, MS Carlon - Cells, 2022 - mdpi.com
Cystic fibrosis (CF) is the most common monogenic disorder, caused by mutations in the CF
transmembrane conductance regulator (CFTR) gene. Over the last 30 years, tremendous …
transmembrane conductance regulator (CFTR) gene. Over the last 30 years, tremendous …
Precise targeting of miRNA sites restores CFTR activity in CF bronchial epithelial cells
C De Santi, EF Fernández, R Gaul, S Vencken… - Molecular Therapy, 2020 - cell.com
MicroRNAs that are overexpressed in cystic fibrosis (CF) bronchial epithelial cells (BEC)
negatively regulate CFTR and nullify the beneficial effects of CFTR modulators. We …
negatively regulate CFTR and nullify the beneficial effects of CFTR modulators. We …
Role of non-coding RNAs in post-transcriptional regulation of lung diseases
Non-coding RNAs (ncRNAs), notably microRNAs (miRNAs) and long noncoding RNAs
(lncRNAs), have recently gained increasing consideration because of their versatile role as …
(lncRNAs), have recently gained increasing consideration because of their versatile role as …
SARS-CoV-2 viral entry and replication is impaired in Cystic Fibrosis airways due to ACE2 downregulation
As an inherited disorder characterized by severe pulmonary disease, cystic fibrosis could be
considered a comorbidity for coronavirus disease 2019. Instead, current clinical evidence …
considered a comorbidity for coronavirus disease 2019. Instead, current clinical evidence …
Multifunctional delivery systems for peptide nucleic acids
The number of applications of peptide nucleic acids (PNAs)—oligonucleotide analogs with a
polyamide backbone—is continuously increasing in both in vitro and cellular systems and …
polyamide backbone—is continuously increasing in both in vitro and cellular systems and …