In general, excitation-contraction coupling in muscle is dependent on membrane
depolarization and hyperpolarization to regulate the opening of voltage-dependent Ca2+ …

Asthma is a disease characterised by reversible contraction of airway smooth muscle. Many
signalling pathways are now known to underlie that contraction, almost all of which revolve …

Stimulation of calcium-activated potassium (KCa) channels in airway smooth muscle cells by
phosphorylation-dependent and membrane-delimited, G protein actions has been reported …

Inspired by cell membranes, with high efficiency and precision separation for water and ions,
development of biomimetic membranes using two-dimensional (2D) materials and …

Ion channels play key roles in determining smooth muscle tone by setting the membrane
potential and allowing Ca2+ influx. Perhaps not surprisingly, therefore, they also provide …

In rat aortic rings contracted by phenylephrine, the relaxation induced by isoprenaline was
partly inhibited by iberiotoxin,(ibTX), tetraethylammonium, 4-aminopyridine (4-AP) and 1, 9 …

Sensory nerves play an important role in airway disease by mediating central reflexes such
as cough, and local axon reflexes resulting in the peripheral release of neuropeptides. We …

Airway smooth muscle contributes to both contractility and inflammation in the
pathophysiology of asthma and COPD. Airway smooth muscle cells can change the degree …

1. In order to determine the physiological role of specific potassium currents in airway
smooth muscle, potassium currents were measured in freshly dissociated ferret trachealis …

Experiments have been performed in order to analyse the mechanism whereby SCA40, a
new imidazo [1, 2-a] pyrazine derivative relaxes airway smooth muscle. 2. SCA40 (0.01-10 …