Molecular mechanisms of regulation of Toll-like receptor signaling

CA Leifer, AE Medvedev - Journal of Leucocyte Biology, 2016 - academic.oup.com
TLRs play a critical role in the detection of microbes and endogenous “alarmins” to initiate
host defense, yet they can also contribute to the development and progression of …

[HTML][HTML] The future exploring of gut microbiome-immunity interactions: from in vivo/vitro models to in silico innovations

S Bertorello, F Cei, D Fink, E Niccolai, A Amedei - Microorganisms, 2024 - mdpi.com
Investigating the complex interactions between microbiota and immunity is crucial for a
fruitful understanding progress of human health and disease. This review assesses animal …

[HTML][HTML] Yogurt starter cultures of Streptococcus thermophilus and Lactobacillus bulgaricus ameliorate symptoms and modulate the immune response in a mouse …

E Wasilewska, D Zlotkowska, B Wroblewska - Journal of Dairy Science, 2019 - Elsevier
We investigated the yogurt starter cultures of Lactobacillus bulgaricus 151 and
Streptococcus thermophilus MK-10 for their effect on the severity of experimental colitis …

Fucoidan extracts ameliorate acute colitis

QY Lean, RD Eri, JH Fitton, RP Patel, N Gueven - PloS one, 2015 - journals.plos.org
Inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease, are an
important cause of morbidity and impact significantly on quality of life. Overall, current …

Elevated apoptosis impairs epithelial cell turnover and shortens villi in TNF-driven intestinal inflammation

A Parker, L Vaux, AM Patterson, A Modasia… - Cell death & …, 2019 - nature.com
The intestinal epithelial monolayer, at the boundary between microbes and the host immune
system, plays an important role in the development of inflammatory bowel disease (IBD) …

Activation of epithelial signal transducer and activator of transcription 1 by interleukin 28 controls mucosal healing in mice with colitis and is increased in mucosa of …

MT Chiriac, B Buchen, A Wandersee, G Hundorfean… - Gastroenterology, 2017 - Elsevier
Background & Aims We investigated the roles of interleukin 28A (also called IL28A or
interferon λ2) in intestinal epithelial cell (IEC) activation, studying its effects in mouse models …

Protective effect of exopolysaccharide fraction from Bacillus subtilis against dextran sulfate sodium-induced colitis through maintenance of intestinal barrier and …

KS Chung, JS Shin, JH Lee, SE Park, HS Han… - International Journal of …, 2021 - Elsevier
We previously reported that an exopolysaccharide-enriched fraction from Bacillus subtilis
J92 (B-EPS) could improve immune functions by regulating the immunological parameters …

[HTML][HTML] Dose titration of FITC-D for optimal measurement of enteric inflammation in broiler chicks

EA Vicuña, VA Kuttappan, G Tellez… - Poultry science, 2015 - Elsevier
Traditionally, antibiotic growth promoters (AGP) have been used in foodstock animals to
reduce enteric inflammation and maintain intestinal homeostasis, thus improving growth and …

Pregnane X receptor agonists enhance intestinal epithelial wound healing and repair of the intestinal barrier following the induction of experimental colitis

J Terc, A Hansen, L Alston, SA Hirota - European journal of pharmaceutical …, 2014 - Elsevier
The intestinal epithelial barrier plays a key role in the maintenance of homeostasis within the
gastrointestinal tract. Barrier dysfunction leading to increased epithelial permeability is …

[HTML][HTML] Longitudinal analysis of inflammation and microbiota dynamics in a model of mild chronic dextran sulfate sodium-induced colitis in mice

L De Fazio, E Cavazza, E Spisni… - World Journal of …, 2014 - ncbi.nlm.nih.gov
AIM: To characterize longitudinally the inflammation and the gut microbiota dynamics in a
mouse model of dextran sulfate sodium (DSS)-induced colitis. METHODS: In animal models …