The endothelial cells lining the brain capillaries separate the blood from the brain
parenchyma. The endothelial monolayer of the brain capillaries serves both as a crucial …

Effective treatment of metastatic cancers usually requires the use of toxic chemotherapy. In
most cases, multiple drugs are used, as resistance to single agents occurs almost …

This review considers efflux of substances from brain parenchyma quantified as values of
clearances (CL, stated in µL g− 1 min− 1). Total clearance of a substance is the sum of …

Traumatic brain injury (TBI) remains a significant source of death and permanent disability,
contributing to nearly one-third of all injury related deaths in the United States and exacting …

In tumor cell lines, multidrug resistance is often associated with an ATP-dependent decrease
in cellular drug accumulation which is attributed to the overexpression of certain ATP …

Studies of the choroid plexus lag behind those of the more widely known blood-brain barrier,
despite a much longer history. This review has two overall aims. The first is to outline long …

Multidrug Resistance Proteins (MRPs), together with the cystic fibrosis conductance
regulator (CFTR/ABCC7) and the sulfonylurea receptors (SUR1/ABCC8 and SUR2/ABCC9) …

The extrusion of anticancer drugs by members of the ATP-binding cassette (ABC)
transporter family is one of the most widely recognized mechanisms of multidrug resistance …

The blood–brain barrier (BBB) serves as a protective mechanism for the brain by preventing
entry of potentially harmful substances from free access to the central nervous system …

The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB) separate
the brain and cerebrospinal fluid (CSF) from the systemic circulation and represent a barrier …