BDNF/TrkB is a crucial regulator in the inflammation-mediated odontoblastic differentiation of dental pulp stem cells

JH Kim, M Irfan, MA Hossain, A George, S Chung - Cells, 2023 - mdpi.com
The odontoblastic differentiation of dental pulp stem cells (DPSCs) associated with caries
injury happens in an inflammatory context. We recently demonstrated that there is a link …

Efficient bone regeneration of BMP9-stimulated human periodontal ligament stem cells (hPDLSCs) in decellularized bone matrix (DBM) constructs to model …

Y Zhang, W Luo, L Zheng, J Hu, L Nie, H Zeng… - Stem Cell Research & …, 2022 - Springer
Abstract Background BMP9-stimulated DPSCs, SCAPs and PDLSCs are effective
candidates for repairing maxillofacial bone defects in tissue engineering, while the most …

[HTML][HTML] Mechanical Signaling in Dental Pulp Stem Cells

J Zhao, W Du, D Guo, S Wang, W Du - Frontiers in Bioscience …, 2023 - imrpress.com
Dental pulp stem cells (DPSCs) are a type of mesenchymal stem cells derived from dental
pulp that serves as an important model for investigating biological regeneration. DPSCs …

LPS-induced inflammation potentiates dental pulp stem cell odontogenic differentiation through C5aR and p38

JH Kim, M Irfan, MA Hossain, S Shin… - Connective Tissue …, 2023 - Taylor & Francis
Aim Inflammation is a complex host response to harmful infection or injury, and it seems to
play a crucial role in tissue regeneration both positively and negatively. We have previously …

Heparin-Functionalized Bioactive Glass to Harvest Endogenous Growth Factors for Pulp Regeneration

J Wu, J Li, S Mao, B Li, L Zhu, P Jia… - … Applied Materials & …, 2024 - ACS Publications
Pulp and periapical diseases can lead to the cessation of tooth development, resulting in
compromised tooth structure and functions. Despite numerous efforts to induce pulp …

Characterization of a Stemness-Optimized Purification Method for Human Dental-Pulp Stem Cells: An Approach to Standardization

MP Dieterle, T Gross, T Steinberg, P Tomakidi… - Cells, 2022 - mdpi.com
Human dental pulp stem cells (hDPSCs) are promising for oral/craniofacial regeneration, but
their purification and characterization is not yet standardized. hDPSCs from three donors …

C5L2 modulates BDNF production in human dental pulp stem cells via p38α pathway

M Irfan, S Chung - Scientific Reports, 2023 - nature.com
Tissue injury affects nerve fibers and triggers an immune response, leading to inflammation.
The complement system gets activated during inflammatory conditions and has been …

C5L2 CRISPR KO enhances dental pulp stem cell-mediated dentinogenesis via TrkB under TNFα-induced inflammation

M Irfan, H Marzban, S Chung - Frontiers in Cell and Developmental …, 2024 - frontiersin.org
Background and Objectives: Dental caries is one of the most common human pathological
conditions resulting from the invasion of bacteria into the dentin. Current treatment options …

Lin28 affects the proliferation and osteogenic differentiation of human dental pulp stem cells by directly inhibiting let-7b maturation

L Yan, J Sun, Y Wang, X Liu, J Hu, M Sun, X Suo… - BDJ open, 2024 - nature.com
Abstract Objective Activation of Lin28 gene under certain conditions promotes tissue
damage repair. However, it remains unknown whether conditional expression of Lin28 …

The role of vitamin D receptor in predentin mineralization and dental repair after injury

Y Liu, Y Wu, X Hu, Y Sun, G Zeng, Q Wang, S Liu… - Cell and Tissue …, 2024 - Springer
Dentin is a permeable and complex tubular composite formed by the mineralization of
predentin that mineralization and repair are of considerable clinical interest during dentin …