Revisiting the Page & Schroeder model: the good, the bad and the unknowns in the periodontal host response 40 years later
G Hajishengallis, JM Korostoff - Periodontology 2000, 2017 - Wiley Online Library
In their classic 1976 paper, Page & Schroeder described the histopathologic events and the
types of myeloid cells and lymphocytes involved in the initiation and progression of …
types of myeloid cells and lymphocytes involved in the initiation and progression of …
Metformin and autoimmunity: a “new deal” of an old drug
Metformin (dimethyl biguanide) is a synthetic derivative of guanidine, isolated from the
extracts of Galega officinalis, a plant with a prominent antidiabetic effect. Since its discovery …
extracts of Galega officinalis, a plant with a prominent antidiabetic effect. Since its discovery …
Mapping the developing human immune system across organs
Single-cell genomics studies have decoded the immune cell composition of several human
prenatal organs but were limited in describing the developing immune system as a …
prenatal organs but were limited in describing the developing immune system as a …
A B1a–natural IgG–neutrophil axis is impaired in viral-and steroid-associated aspergillosis
The lung naturally resists Aspergillus fumigatus (Af) in healthy individuals, but multiple
conditions can disrupt this resistance, leading to lethal invasive infections. Core processes …
conditions can disrupt this resistance, leading to lethal invasive infections. Core processes …
MYC instructs and maintains pancreatic adenocarcinoma phenotype
The signature features of pancreatic ductal adenocarcinoma (PDAC) are its
fibroinflammatory stroma, poor immune activity, and dismal prognosis. We show that acute …
fibroinflammatory stroma, poor immune activity, and dismal prognosis. We show that acute …
Extracellular CIRP decreases Siglec-G expression on B-1a cells skewing them towards a pro-inflammatory phenotype in sepsis
Background Sepsis is a life-threatening disease syndrome caused by a dysregulated host
response to infection and injury. Extracellular cold-inducible RNA-binding protein (eCIRP) …
response to infection and injury. Extracellular cold-inducible RNA-binding protein (eCIRP) …
The unsolved jigsaw puzzle of the immune response in Chagas disease
GR Acevedo, MC Girard, KA Gómez - Frontiers in immunology, 2018 - frontiersin.org
Trypanosoma cruzi interacts with the different arms of the innate and adaptive host's immune
response in a very complex and flowery manner. The history of host-parasite co-evolution …
response in a very complex and flowery manner. The history of host-parasite co-evolution …
Natural antibodies–facts known and unknown
J Palma, B Tokarz-Deptuła, J Deptuła… - … European Journal of …, 2018 - termedia.pl
In contrast to adaptive antibodies, natural antibodies are present in a non-immunised
organism from birth, and they do not include anti-Gal antibodies and/or anti-Gal natural …
organism from birth, and they do not include anti-Gal antibodies and/or anti-Gal natural …
Cytokine production by human B cells: role in health and autoimmune disease
NM de Gruijter, B Jebson… - Clinical and Experimental …, 2022 - academic.oup.com
B cells are classically considered solely as antibody-producing cells driving humoral
immune responses to foreign antigens in infections and vaccinations as well as self …
immune responses to foreign antigens in infections and vaccinations as well as self …
B-1a cells protect mice from sepsis-induced acute lung injury
M Aziz, Y Ode, M Zhou, M Ochani, NE Holodick… - Molecular …, 2018 - Springer
Background Sepsis morbidity and mortality are aggravated by acute lung injury (ALI) or
acute respiratory distress syndrome (ARDS). Mouse B-1a cells are a phenotypically and …
acute respiratory distress syndrome (ARDS). Mouse B-1a cells are a phenotypically and …