The role of ABCG2 in the pathogenesis of primary hyperuricemia and gout—an update

R Eckenstaler, RA Benndorf - International Journal of Molecular Sciences, 2021 - mdpi.com
Urate homeostasis in humans is a complex and highly heritable process that involves ie,
metabolic urate biosynthesis, renal urate reabsorption, as well as renal and extrarenal urate …

Inflammasomes link vascular disease with neuroinflammation and brain disorders

N Lénárt, D Brough, Á Dénes - Journal of Cerebral Blood …, 2016 - journals.sagepub.com
The role of inflammation in neurological disorders is increasingly recognised. Inflammatory
processes are associated with the aetiology and clinical progression of migraine, psychiatric …

Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population

H Matsuo, T Takada, K Ichida, T Nakamura… - Science translational …, 2009 - science.org
Gout based on hyperuricemia is a common disease with a genetic predisposition, which
causes acute arthritis. The ABCG2/BCRP gene, located in a gout-susceptibility locus on …

Common dysfunctional variants in ABCG2 are a major cause of early-onset gout

H Matsuo, K Ichida, T Takada, A Nakayama… - Scientific reports, 2013 - nature.com
Gout is a common disease which mostly occurs after middle age, but more people
nowadays develop it before the age of thirty. We investigated whether common dysfunction …

Gout as a risk factor for myocardial infarction and stroke in England: evidence from record linkage studies

OO Seminog, MJ Goldacre - Rheumatology, 2013 - academic.oup.com
Objective. Some studies suggest that gout is a risk factor for cardiovascular disease. There is
more evidence about the association between gout and acute myocardial infarction (MI) …

Treatment of acute gouty arthritis in complex hospitalized patients with anakinra

P Ghosh, M Cho, G Rawat, PA Simkin… - Arthritis care & …, 2013 - Wiley Online Library
Objective To report our experience with the efficacy and safety of anakinra for acute gouty
arthritis in medically complex hospitalized patients. Methods We reviewed the hospital …

A common variant of organic anion transporter 4 (OAT4/SLC22A11) gene is associated with renal underexcretion type gout

M Sakiyama, H Matsuo, S Shimizu… - Drug metabolism and …, 2014 - Elsevier
Gout, a common disease, is a consequence of hyperuricemia, and increases the risks of
hypertension, cardiovascular diseases, cerebrovascular diseases and renal failure. Gout …

Lifestyle factors predict gout outcomes: Results from the NOR-Gout longitudinal 2-year treat-to-target study

T Uhlig, LF Karoliussen, J Sexton, TK Kvien… - RMD open, 2023 - rmdopen.bmj.com
Objective Gout is associated with lifestyle, body mass index (BMI) and comorbidities,
including dyslipidaemia. We studied how in actively treated patients, anthropometric …

Recent advances in management of gout

E Suresh, P Das - QJM: An International Journal of Medicine, 2012 - academic.oup.com
Incidence and prevalence of gout have markedly increased over the last few decades in
keeping with the rise in prevalence of obesity and metabolic syndrome. Until recently …

Development of a prediction model for inpatient gout flares in people with comorbid gout

K Jatuworapruk, R Grainger, N Dalbeth… - Annals of the Rheumatic …, 2020 - ard.bmj.com
Objectives Hospitalisation is a risk factor for flares in people with gout. However, the
predictors of inpatient gout flare are not well understood. The aim of this study was to …