1, 2, 3‐Triazole hybrids as anticancer agents: A review
MM Alam - Archiv der Pharmazie, 2022 - Wiley Online Library
Despite the advancements in the development of anticancer agents, more effective and
safer anticancer drugs still need to be developed as the current agents cause unwanted side …
safer anticancer drugs still need to be developed as the current agents cause unwanted side …
Synthesis, characterization, and biological evaluation of some novel Schiff bases as potential metabolic enzyme inhibitors
In this study, a series of novel Schiff base derivatives containing a pyrazolone ring (2a–e)
were designed, successfully synthesized for the first time, and characterized by elemental …
were designed, successfully synthesized for the first time, and characterized by elemental …
Design, synthesis and molecular docking and ADME studies of novel hydrazone derivatives for AChE inhibitory, BBB permeability and antioxidant effects
Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disease that is
characterized by memory and cognitive impairments that predominantly affects the elderly …
characterized by memory and cognitive impairments that predominantly affects the elderly …
1, 2, 3-Triazole substituted phthalocyanine metal complexes as potential inhibitors for anticholinesterase and antidiabetic enzymes with molecular docking studies
In recent years, acetylcholinesterase (AChE) and α-glycosidase (α-gly) inhibition have
emerged as a promising and important approach for pharmacological intervention in many …
emerged as a promising and important approach for pharmacological intervention in many …
Identifying highly effective coumarin-based novel cholinesterase inhibitors by in silico and in vitro studies
Inhibition of high cholinesterase levels including acetylcholinesterase (AChE) and
butyrylcholinesterase (BChE), is one of the most important strategies for the treatment of …
butyrylcholinesterase (BChE), is one of the most important strategies for the treatment of …
Design, synthesis, metal chelation potential and biological evaluation of pyridine chalcones as multi-target-directed ligands against Alzheimer's disease
G Dixit, A Prabhu - Journal of Molecular Structure, 2023 - Elsevier
Abstract Two sets of 1-phenyl-3-(pyridinyl) prop‑2-en-1-one analogs, 7a-d and 8a-d were
designed by the incorporation of pyridine and chalcone privileged scaffolds with the …
designed by the incorporation of pyridine and chalcone privileged scaffolds with the …
Synthesis of novel 1, 2, 3-triazole-tethered N-acyl hydrazones as a new class of carbonic anhydrase II inhibitors: In vitro and in silico potentials
Abstract Carbonic anhydrase II (CA II) is crucial for maintaining homeostasis in several
processes, including respiration, lipogenesis, gluconeogenesis, calcification, bone …
processes, including respiration, lipogenesis, gluconeogenesis, calcification, bone …
Cytotoxicity effects and biochemical investigation of novel tetrakis-phthalocyanines bearing 2-thiocytosine moieties with molecular docking studies
In this study, the novel 3-(4-aminopyrimidin-2-ylthio) phthalonitrile (1) as starting material
was synthesized and its molecular structure was verified by the experiment of single crystal …
was synthesized and its molecular structure was verified by the experiment of single crystal …
Design, synthesis of novel peripherally tetra-chalcone substituted phthalocyanines and their inhibitory effects on acetylcholinesterase and carbonic anhydrases (hCA I …
T Arslan - Journal of Organometallic Chemistry, 2021 - Elsevier
In this work, phthalocyanine precursor (3), tetra-chalcone substituted metal-free (4) and
metallo phthalocyanines (5, 6, 7) were synthesized for the first time and surveyed …
metallo phthalocyanines (5, 6, 7) were synthesized for the first time and surveyed …
Biological activity and molecular docking studies of some N‐phenylsulfonamides against cholinesterases and carbonic anhydrase isoenzymes
In this research, a series of N‐phenylsulfonamide derivatives (1‐12) were designed,
synthesized, and investigated for their inhibitory potencies against carbonic anhydrase …
synthesized, and investigated for their inhibitory potencies against carbonic anhydrase …