Background The remarkable growth of genome-wide association studies (GWAS) has
created a critical need to experimentally validate the disease-associated variants, 90% of …

The vast majority of the genetic variants (mainly SNPs) associated with various human traits
and diseases map to a noncoding part of the genome and are enriched in its regulatory …

The discovery of genetic loci associated with complex diseases has outpaced the
elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide …

Rationale: Arterial inflammation manifested as atherosclerosis is the leading cause of
mortality worldwide. Genome-wide association studies have identified a prominent role of …

Background: The inhibition of histone deacetylase 9 (HDAC9) represents a promising
druggable target for stroke intervention. Indeed, HDAC9 is overexpressed in neurons after …

Atherosclerosis (AS), the most common underlying pathology for coronary artery disease, is
a chronic inflammatory, proliferative disease in large-and medium-sized arteries. The …

Abstract Background HDAC9 (histone deacetylase 9) belongs to the class IIa family of
histone deacetylases. This enzyme can shuttle freely between the nucleus and cytoplasm …

The identification of a variant in the HDAC9 gene as a risk factor for large-artery
atherosclerotic stroke, and subsequently coronary artery disease, has opened novel …

Cardiovascular diseases are among the leading causes of mortality worldwide. Besides
environmental and genetic changes, these disorders can be influenced by processes which …

Atherosclerosis (AS) features include progressive hardening and reduced elasticity of
arteries. AS is the leading cause of morbidity and mortality. An increasing amount of …