During the last decade, experimental research has demonstrated a prominent role of glial
cells, activated in brain by various injuries, in the mechanisms of seizure precipitation and …

Cytokines are molecules secreted by peripheral immune cells, microglia, astrocytes and
neurons in the central nervous system. Peripheral or central inflammation is characterized …

I. Introduction THE existence of mechanisms that provide immunity to an infective agent was
inferred from empirical observations obtained through the ingenuity and deductive capacity …

Inflammatory reactions occur in the brain in various CNS diseases, including autoimmune,
neurodegenerative, and epileptic disorders. Proinflammatory and antiinflammatory cytokines …

Using immunocytochemistry and ELISA, we investigated the production of interleukin (IL)-1β
in the rat hippocampus after focal application of kainic acid inducing …

Cytokines are a heterogeneous group of polypeptide mediators that have been aswciakd
classically wlth activation of the lmmune system and inflammatory responses. An incmasing …

IL-1β and its endogenous receptor antagonist (IL-1Ra) are rapidly induced by seizures in
the rodent hippocampus. Exogenously applied IL-1β prolongs seizures in an IL-1R type I …

Epilepsy is a common chronic neurological disorder affecting approximately 8 out of 1000
people. Its pathophysiology, however, has remained elusive in many regards …

The effects of the cytokine, Interleukin-1β (IL-1β), and its receptor antagonist IL-1ra, were
studied on long-term potentiation in the dentate gyrus of rat hippocampal slices. Field …

Abstract Interleukin-1 (IL-1) synthesis in the brain is stimulated by mechanical injury and IL-1
mimics some effects of injury, such as gliosis and neovascularization. We report that …