Arrhythmic risk stratification among patients with hypertrophic cardiomyopathy

F Santoro, F Mango, A Mallardi… - Journal of Clinical …, 2023 - mdpi.com
Hypertrophic cardiomyopathy (HCM) is a cardiac muscle disorder characterized by
generally asymmetric abnormal hypertrophy of the left ventricle without abnormal loading …

Hypertrophic cardiomyopathy: Genetic foundations, outcomes, interconnections, and their modifiers

M Glavaški, L Velicki, N Vučinić - Medicina, 2023 - mdpi.com
Hypertrophic cardiomyopathy (HCM) is the most prevalent heritable cardiomyopathy. HCM
is considered to be caused by mutations in cardiac sarcomeric protein genes. Recent …

Mangiferin Protects against Angiotensin-II-Enhanced Hypertrophic Markers and Apoptosis in H9c2 Cardiomyocytes

CC Chang, KL Tsai, HC Cheng, WC Chou… - The American Journal …, 2023 - World Scientific
Hypertrophic cardiomyopathy accompanies numerous cardiovascular diseases, and the
intervention of cardiac hypertrophy is an important issue to prevent detrimental …

Deciphering metabolomics and lipidomics landscape in zebrafish hypertrophic cardiomyopathy model

S Jacob, T Abuarja, R Shaath, W Hasan, S Balayya… - Scientific Reports, 2024 - nature.com
To elucidate the lipidomic and metabolomic alterations associated with hypertrophic
cardiomyopathy (HCM) pathogenesis, we utilized cmybpc3-/-zebrafish model. Fatty acid …

Clinical significance of genetic variation in hypertrophic cardiomyopathy: comparison of computational tools to prioritize missense variants

P Barbosa, M Ribeiro, M Carmo-Fonseca… - Frontiers in …, 2022 - frontiersin.org
Hypertrophic cardiomyopathy (HCM) is a common heart disease associated with sudden
cardiac death. Early diagnosis is critical to identify patients who may benefit from …

[HTML][HTML] Hypertrophic Cardiomyopathy with Special Focus on Mavacamten and Its Future in Cardiology

E Młynarska, E Radzioch, B Dąbek, K Leszto… - Biomedicines, 2024 - mdpi.com
Hypertrophic cardiomyopathy (HCM) is a heterogeneous group of heart muscle disorders
that affects millions, with an incidence from 1 in 500 to 1 in 200. Factors such as genetics …

[HTML][HTML] Pathological Alterations in Heart Mitochondria in a Rat Model of Isoprenaline-Induced Myocardial Injury and Their Correction with Water-Soluble Taxifolin

NV Belosludtseva, TA Uryupina, LL Pavlik… - International Journal of …, 2024 - mdpi.com
Mitochondrial damage and associated oxidative stress are considered to be major
contributory factors in cardiac pathology. One of the most potent naturally occurring …

An Investigation of Metabolic Risk Factors and Gut Microbiota in Unexplained Syncope

S Longo, F Del Chierico, M Scanu, F Toto… - Biomedicines, 2024 - mdpi.com
Background: The pathogenesis of many syncopal episodes remains unexplained. Intestinal
dysbiosis could be involved in the pathophysiological mechanisms of syncope due to its …

Necroptosis and immune infiltration in hypertrophic cardiomyopathy: novel insights from bioinformatics analyses

C Hou, S Fei, F Jia - Frontiers in Cardiovascular Medicine, 2024 - frontiersin.org
Background Hypertrophic Cardiomyopathy (HCM), a widespread genetic heart disorder, is
largely associated with sudden cardiac fatality. Necroptosis, an emerging type of …

Validation of the risk stratification for sudden cardiac death in Chinese patients with hypertrophic cardiomyopathy

W Qi, L Pu, J Zhang, H Chen, Z Tang, J Wang… - Current Problems in …, 2023 - Elsevier
Accurate identification of hypertrophic cardiomyopathy (HCM) patients at high risk of sudden
cardiac death (SCD) event is challenging. The objective of this study was to validate the …